Verapamil Hydrochloride EP Impurity E CAS 93-03-8
| CAS No. | 93-03-8 |
| Molecular Formula | C9H12O3 |
| Molecular Weight | 168.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Verapamil Hydrochloride EP Impurity E (CAS 93-03-8), a pharmacopoeial impurity reference standard (molecular formula C9H12O3, MW 168.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C9H12O3, Verapamil Hydrochloride EP Impurity E contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 168.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Verapamil Hydrochloride EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12O3 |
| Molecular Weight | 168.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Verapamil Standards
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil Impurity 24 (CAS 18086-24-3)
- Verapamil Impurity N2 (CAS 3017-96-7)
- Verapamil Impurity 25 (CAS 3893-01-4)
- Verapamil Impurity 27 (CAS 7306-46-9)
- Verapamil EP Impurity B (CAS 3490-06-0)
- Verapamil EP Impurity L (CAS 14046-55-0)
- Verapamil EP Impurity C (CAS 3490-05-9)
Recommended Standards
- Bisoprolol Impurity 68 (CAS 325147-81-7)
- Norepinephrine impurity 147 (CAS CATO-C4X-1514147)
- Salbutamol Impurity 93 (CAS 141024-79-5)
- Carvedilol impurity 8 (CAS 18181-71-0)
- Sofosbuvir Impurity 70 (CAS 1334513-02-8)
- Avibactam Impurity 44 (CAS CATO-C4X-134844)
- Mirabegron Impurity 73 (CAS 100-12-9)
- Beclometasone Dipropionate Monohydrate EP Impurity U (CAS 79578-39-5)
- N-Nitroso Tosufloxacin impurity 7 (CAS CATO-C4X-19767)
- 1-(4-Tert-butylphenyl)-2-methylpropan-1-one (CAS 60561-82-2)
- 1-Ethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (CAS 866039-96-5)
- 2-(4-Fluoro-3-nitrophenyl)acetonitrile (CAS 157662-77-6)
- Methyl 2-amino-3-bromo-5-(trifluoromethyl)benzoate (CAS 1805624-33-2)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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