Doxorubicin Impurity 24 CAS CATO-C4X-203324
| CAS No. | CATO-C4X-203324 |
| Molecular Formula | C21H16O8 |
| Molecular Weight | 396.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Doxorubicin Impurity 24.
As a process- or degradation-related impurity, Doxorubicin Impurity 24 (CAS CATO-C4X-203324, C21H16O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Doxorubicin Impurity 24 (C21H16O8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H16O8 |
| Molecular Weight | 396.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Doxorubicin Standards
- Doxorubicin Impurity 36 (CAS CATO-C4X-203336)
- Doxorubicin Dimer Impurity 17 (CAS 59325-98-3)
- Doxorubicin Impurity 5 (CAS 1159977-23-7)
- Doxorubicin Impurity 39 (Mixture of Diastereomers) (CAS 210837-87-9)
- Doxorubicin Impurity 14 (CAS CATO-C4X-203314)
- Doxorubicin Impurity 7 (CAS 105612-58-6)
- Doxorubicin Impurity 8 (CAS 20982-41-6)
- Doxorubicin Impurity 6 (CAS 32384-98-8)
Recommended Standards
- Etoposide EP Impurity P (CAS 117669-31-5)
- Diacerein Impurity 8 (CAS 6030-60-0)
- Vericiguat Impurity 67 (CAS 2755814-39-0)
- Diacerein EP Impurity H (CAS 25395-11-3)
- Bilastine Impurity 47 (CAS CATO-C4X-225347)
- Aripiprazole Impurity 75 (CAS 1782324-31-5)
- Papaverine Impurity 39 (CAS 75608-42-3)
- (1-(6-Chloropyrimidin-4-yl)azetidin-3-yl)methanol (CAS 1420871-29-9)
- 1-Isopropyl-3-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbaldehyde (CAS 61619-66-7)
- Dibenzo[c,h]acridine (CAS 224-53-3)
- Glycerol carbonate-(<i>carbonyl</i>-<sup>13</sup>C) (CAS 1379618-83-3)
- Sodium 2-thioxopyridin-1(2H)-olate (CAS 15922-78-8)
- 5-(2,3,4-trifluorobenzyl)-1,3-thiazol-2-amine (CAS 926188-02-5)
- Dulaglutide (CAS 923950-08-7)
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