Trimetazidine Dihydrochloride EP Impurity C CAS 2103-57-3
| CAS No. | 2103-57-3 |
| Molecular Formula | C10H12O4 |
| Molecular Weight | 196.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Trimetazidine Dihydrochloride EP Impurity C is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Trimetazidine Dihydrochloride EP Impurity C (CAS 2103-57-3), a pharmacopoeial impurity reference standard (molecular formula C10H12O4, MW 196.20 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Trimetazidine Dihydrochloride EP Impurity C (C10H12O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Trimetazidine Dihydrochloride EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12O4 |
| Molecular Weight | 196.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Trimetazidine Standards
- Trimetazidine Impurity 22 (CAS 86-81-7)
- Trimetazidine impurity 34 (CAS CATO-C4X-180334)
- Trimetazidine EP Impurity D (CAS 71989-96-3)
- Trimetazidine Impurity 21 (CAS 69471-05-2)
- Trimetazidine Impurity 20 (CAS 573-11-5)
- Trimetazidine Impurity 5 (CAS 1133-49-9)
- Trimetazidine Impurity 11 (CAS CATO-C4X-180311)
- Trimetazidine Impurity 12 (CAS 169506-15-4)
Recommended Standards
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- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
Why CATO?
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