Apixaban Impurity 6 CAS 1074365-84-6
| CAS No. | 1074365-84-6 |
| Molecular Formula | C26H26N4O5 |
| Molecular Weight | 474.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apixaban Impurity 6.
CATO supplies Apixaban Impurity 6 (CAS 1074365-84-6), a pharmacopoeial impurity reference standard (molecular formula C26H26N4O5, MW 474.51 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Apixaban Impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 474.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H26N4O5 |
| Molecular Weight | 474.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 4 |
Related Apixaban Standards
- Apixaban Impurity 137 (CAS CATO-C4X-1088137)
- Apixaban Impurity 155 (CAS 1928718-22-2)
- Apixaban Impurity 164 (CAS CATO-C4X-1088164)
- Apixaban Impurity 3 (BMS-778960-01) (CAS 2098457-92-0)
- Apixaban Impurity 4 (BMS-728626-01) (CAS 1686149-74-5)
- Apixaban Impurity 8 (CAS 1074549-87-3)
- Apixaban Impurity 87 (CAS CATO-C4X-108887)
- Apixaban Impurity 88 (CAS CATO-C4X-108888)
Recommended Standards
- Ibrutinib Impurity 13 (Mixture of Diastereomers) (CAS 1654820-87-7)
- Racecadotril Impurity 11 (CAS CATO-C4X-110611)
- Z-Dbu(Fmoc) (R) (CAS 349547-09-7)
- Isavuconazole Impurity 204 (CAS CATO-C4X-1236204)
- Tedizolid Impurity 96 (CAS CATO-C4X-105496)
- Irinotecan EP Impurity H HCl (CAS CATO-C4X-15714)
- Diquafosol Impurity 34 (CAS 211448-81-6(free base))
- tert-Butyl (2-benzoyl-4-bromophenyl)carbamate (CAS 341521-31-1)
- 2-(Tetrahydro-2h-pyran-4-yl)pyrimidin-5-amine (CAS 1248691-42-0)
- 1-Methyl-1H-1,2,3-triazol-5-ol (CAS 62150-39-4)
- 1-(1,3-benzodioxol-5-ylmethyl)-1H-indole-2,3-dione (CAS 354781-32-1)
- Afoxolaner impurity 3 (CAS CATO-C4X-31373)
- 1-[(1-ethyl-5-methyl-1h-pyrazol-4-yl)methyl]piperidine-4-carboxylic acid (CAS 1006483-74-4)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com