Posaconazole Impurity 18(R,S,S,R) CAS 213381-06-7
| CAS No. | 213381-06-7 |
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Posaconazole Impurity 18(R,S,S,R) (CAS 213381-06-7) is a certified pharmaceutical impurity reference standard with the molecular formula C37H42F2N8O4 and a molecular weight of 700.78 g/mol.
Based on its molecular formula C37H42F2N8O4, Posaconazole Impurity 18(R,S,S,R) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 700.78 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2017 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Posaconazole Standards
- Posaconazole (CAS 171228-49-2)
- Posaconazole Impurity 12(S,S,R,R) (CAS 2243785-97-7)
- Posaconazole Impurity 13(R,R,R,R) (CAS 170985-61-2)
- Posaconazole Impurity 14(S,R,R,R) (CAS 213381-05-6)
- Posaconazole Impurity 15(S,S,S,S) (CAS 1246391-73-0)
- Posaconazole Impurity 157 (CAS CATO-C4X-1208157)
- Posaconazole Impurity 16(S,R,S,S) (CAS 213381-02-3)
- Posaconazole Impurity 17(R,R,R,S) (CAS 171228-51-6)
Recommended Standards
- Posaconazole Impurity 176 (CAS CATO-C4X-1208176)
- Posaconazole Impurity 19(S,S,R,S) (CAS 2243785-99-9)
- Posaconazole Impurity 20(R,S,R,S) (CAS 1229428-91-4)
- Posaconazole Impurity 21(R,R,S,R) (CAS 171228-50-5)
- Dexrazoxane Impurity 32 (CAS CATO-C4X-202032)
- Isavuconazole Impurity 39 (CAS CATO-C4X-123639)
- Gadobutrol Impurity 111 (CAS 619-73-8)
- Fmoc-3-bromo-L-phenylalanine (CAS 220497-48-3)
- (S)-tert-Butyl 1-(2-amino-4-fluorophenyl)pyrrolidin-3-ylcarbamate (CAS 1233860-02-0)
- 4-(Bromomethyl)-6-fluoro-3,3'-bipyridine (CAS 1227587-91-8)
- tert-Butyl ((1H-benzo[d][1,2,3]triazol-1-yl)methyl)(propyl)carbamate (CAS 1131148-50-9)
- Bromocyclopropane-2,2,3,3-d4 (CAS 1398065-55-8)
- 1-(4-Bromo-5-fluoro-2-nitrophenyl)ethan-1-ol (CAS 2658494-13-2)
- Bonemarrow-Derived Mesenchymal Stem Cells Affinity Peptide trifluoroacetate salt (CAS 683750-83-6)
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