Posaconazole Impurity 176 CAS CATO-C4X-1208176
| CAS No. | CATO-C4X-1208176 |
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Posaconazole Impurity 176 (CAS CATO-C4X-1208176) is a certified pharmaceutical impurity reference standard with the molecular formula C37H42F2N8O4 and a molecular weight of 700.78 g/mol.
The molecular framework of Posaconazole Impurity 176 (C37H42F2N8O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Posaconazole Impurity 176 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Posaconazole Standards
- Posaconazole (CAS 171228-49-2)
- Posaconazole Impurity 12(S,S,R,R) (CAS 2243785-97-7)
- Posaconazole Impurity 13(R,R,R,R) (CAS 170985-61-2)
- Posaconazole Impurity 14(S,R,R,R) (CAS 213381-05-6)
- Posaconazole Impurity 15(S,S,S,S) (CAS 1246391-73-0)
- Posaconazole Impurity 157 (CAS CATO-C4X-1208157)
- Posaconazole Impurity 16(S,R,S,S) (CAS 213381-02-3)
- Posaconazole Impurity 17(R,R,R,S) (CAS 171228-51-6)
Recommended Standards
- Posaconazole Impurity 18(R,S,S,R) (CAS 213381-06-7)
- Posaconazole Impurity 19(S,S,R,S) (CAS 2243785-99-9)
- Posaconazole Impurity 20(R,S,R,S) (CAS 1229428-91-4)
- Posaconazole Impurity 21(R,R,S,R) (CAS 171228-50-5)
- Nebivolol Impurity 68 (CAS CATO-C4X-196868)
- Aztreonam USP RC A Sodium salt (CAS 87500-74-1(Free Base))
- Mitoxantrone EP Impurity A (CAS 89991-52-6)
- [1,2,4]Triazolo[4,3-b]pyridazine-7-carboxylic acid (CAS 127478-29-9)
- (4-(4-Methoxyphenyl)thiophen-2-yl)methanol (CAS 79757-72-5)
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- 2-(Chloromethyl)-6-(difluoromethyl)-3-methoxy-4-nitropyridine (CAS 1805434-69-8)
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