Clotrimazole Impurity 12 CAS 15145-69-4
| CAS No. | 15145-69-4 |
| Molecular Formula | C7H5Cl3 |
| Molecular Weight | 195.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 195.47 g/mol gives Clotrimazole Impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Clotrimazole Impurity 12 (CAS 15145-69-4), a pharmacopoeial impurity reference standard (molecular formula C7H5Cl3, MW 195.47 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Clotrimazole Impurity 12 (C7H5Cl3) contains chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 195.47 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5Cl3 |
| Molecular Weight | 195.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole Impurity 26 (CAS 29921-41-3)
- Clotrimazole Impurity 20 (CAS 3005-50-3)
- Clotrimazole EP Impurity E (CAS 5162-03-8)
- Clotrimazole Impurity 11 (CAS 611-19-8)
- Clotrimazole Impurity 15 (CAS 2136-81-4)
- Clotrimazole Impurity 13 (CAS 108-41-8)
- Clotrimazole Impurity 25 (CAS 3509-85-1)
- Clotrimazole Impurity 27 (CAS 56153-60-7)
Recommended Standards
- Felodipine Impurity 10 (CAS 3290-01-5)
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- 3,4-Dichlorobenzyl Chloride (CAS 102-47-6)
- Ibrutinib Impurity 112 (CAS CATO-C4X-1064112)
- Cefaclor Impurity 33 (CAS CATO-C4X-127033)
- Ethinylestradiol EP Impurity L (CAS 57-91-0)
- (R)-3-amino-N-(1-phenylethyl)propanamide (CAS 88574-55-4)
- 5-(Tert-butyl)-4-phenylthiazol-2-amine (CAS 101853-12-7)
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- 2-Chloro-5-nitro-3-phenylpyridine (CAS 1119088-46-8)
- 3-(2,3-Dihydroimidazo[2,1-b]thiazol-6-yl)aniline (CAS 1105195-14-9)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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