Raltegravir EP Impurity F CAS 2138805-56-6
| CAS No. | 2138805-56-6 |
| Molecular Formula | C22H27FN6O6 |
| Molecular Weight | 490.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Raltegravir EP Impurity F (CAS 2138805-56-6, C22H27FN6O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H27FN6O6, Raltegravir EP Impurity F contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 490.48 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H27FN6O6 |
| Molecular Weight | 490.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Raltegravir Standards
- Raltegravir-d3 Potassium Salt (CAS 1246816-98-7)
- Raltegravir Impurity 9 (CAS 518048-02-7)
- Raltegravir EP Impurity C (CAS 1391918-17-4)
- Raltegravir Impurity15 (CAS 519028-33-2)
- Raltegravir -D6 (CAS 1100750-98-8)
- Raltegravir (CAS 518048-05-0)
- Raltegravir 5-Methoxy Impurity (CAS CATO-C4X-26158)
- Raltegravir EP Impurity E (CAS 1193687-87-4)
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- 6-Ethyl-5-fluoro-1H-indole (CAS 1510828-27-9)
- Itraconazole Impurity 15 (CAS 2508172-07-2)
- 4-Chloro-3-isopropylbenzonitrile (CAS 1349716-25-1)
- 2-(4-Methoxy-2-methylphenyl)ethan-1-ol (CAS 30888-95-0)
- N-(3,5-dimethylphenyl)-2,4-dimethoxy-3-methylbenzenesulfinamide (CAS 338981-88-7)
- Semaglutide Impurity 14(Discontinued,See CPTD788307 ) (CAS CATO-C4X-222614)
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