Benazepril EP Impurity A HCl CAS 215447-89-5
| CAS No. | 215447-89-5 |
| Molecular Formula | C24H28N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Benazepril EP Impurity A HCl (CAS 215447-89-5) is a certified pharmaceutical impurity reference standard with the molecular formula C24H28N2O5HCl and a molecular weight of 460.96 g/mol.
Structurally, Benazepril EP Impurity A HCl (C24H28N2O5HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 460.96 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H28N2O5 HCl |
| Molecular Weight | 460.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Benazepril Standards
- Benazepril Hydrochloride EP Impurity G Hydrochloride (CAS 103129-58-4)
- Benazepril Impurity 2 (CAS 105260-10-4)
- Benazepril EP Impurity F (CAS 109010-60-8)
- Benazepril tert-Butyl Ester (CAS 109010-61-9)
- Benazepril EP Impurity D (CAS 112110-48-2)
- Benazepril-d5 HCl (CAS 1279026-26-4)
- Benazepril-d5 (CAS 1279200-03-1)
- Benazepril EP Impurity A (CAS 131064-75-0)
Recommended Standards
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- 201740-95-6 (~13~C_6_)Phenylmethanol DTXSID70584347 (CAS 201740-95-6)
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- Methyl 2-(benzo[d]thiazol-2-ylthio)acetate (CAS 24044-87-9)
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- N-(4-cyanophenyl)methacrylamide (CAS 90617-02-0)
- 3,4-Difluoro-5-nitrobenzoic acid (CAS 1121583-51-4)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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