Carfilzomib Impurity 75 CAS 2381627-87-6
| CAS No. | 2381627-87-6 |
| Molecular Formula | C14H25NO4 |
| Molecular Weight | 271.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Carfilzomib Impurity 75 (CAS 2381627-87-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H25NO4 and a molecular weight of 271.35 g/mol.
The molecular framework of Carfilzomib Impurity 75 (C14H25NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H25NO4 |
| Molecular Weight | 271.35 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Related Carfilzomib Standards
- Carfilzomib Impurity 11 (CAS 247068-82-2)
- Carfilzomib Impurity 50 (CAS 129603-01-6)
- CarfilzomiB impurity 12 (CAS 100564-78-1)
- Carfilzomib Impurity 92 (CAS CATO-C4X-102292)
- Carfilzomib Impurity 47 (CAS 72080-89-8)
- Carfilzomib Impurity 87 (CAS CATO-C4X-102287)
- Carfilzomib Impurity 28 (CAS 143415-51-4)
- Carfilzomib Impurity 34 (CAS 247068-81-1)
Recommended Standards
- Atorvastatin Impurity 140 (CAS CATO-C4X-1132140)
- methyl 2-(4-((tert-butoxycarbonyl)amino)cyclohexyl)acetate (CAS 946716-17-2)
- Mianserin Impurity 97 (CAS 85141-92-0)
- trans-Methyl 4-((tert-butoxycarbonyl)(methyl)amino)cyclohexanecarboxylate (CAS 400899-07-2)
- Esomeprazole Impurity 39 (CAS 92806-98-9)
- Afatinib Impurity 92 (CAS 2226537-61-5)
- Epinastine Impurity 24 (CAS 1110929-19-5)
- N-(3-Bromo-4-fluorophenyl)acrylamide (CAS 1567043-72-4)
- Ethyl N-[(2E)-2-[2-(3-methoxyphenyl)hydrazin-1-ylidene]-3-oxobutanoyl]carbamate (CAS 338400-93-4)
- (4-(3-Chlorophenyl)piperazin-1-yl)(pyrrolidin-2-yl)methanone (CAS 1163139-33-0)
- Methyl 3-(6-methoxypyridazin-3-yl)propiolate (CAS 1706433-06-8)
- N-(4-Ethylphenyl)tetrahydrofuran-2-carboxamide (CAS 549499-72-1)
- 2-Methyl-5-(p-tolyl)-1H-pyrrole-3-carboxylic acid (CAS 1225509-91-0)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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