Apixaban Impurity 2 CAS 2187409-01-2
| CAS No. | 2187409-01-2 |
| Molecular Formula | C25H28N6O4 |
| Molecular Weight | 476.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Apixaban Impurity 2 (CAS 2187409-01-2, C25H28N6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Apixaban Impurity 2 (C25H28N6O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H28N6O4 |
| Molecular Weight | 476.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 6 |
Related Apixaban Standards
- Apixaban Impurity 13 (CAS CATO-C4X-108813)
- Apixaban Impurity 39 (CAS 2206825-87-6)
- Apixaban Impurity 40 (CAS 2206825-81-0)
- Apixaban Impurity 65 (CAS 2264018-89-3)
- Apixaban Impurity 6 (CAS 1074365-84-6)
- Apixaban Impurity 137 (CAS CATO-C4X-1088137)
- Apixaban Impurity 155 (CAS 1928718-22-2)
- Apixaban Impurity 164 (CAS CATO-C4X-1088164)
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