2-Chloro-4-methoxyphenylboronic Acid CAS 219735-99-6
| CAS No. | 219735-99-6 |
| Molecular Formula | C7H8BClO3 |
| Molecular Weight | 186.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloro-4-methoxyphenylboronic Acid (C7H8BClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2-Chloro-4-methoxyphenylboronic Acid (CAS 219735-99-6) is a high-purity analytical reference standard with the molecular formula C7H8BClO3 and a molecular weight of 186.40 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8BClO3 |
| Molecular Weight | 186.40 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 2-Chloro-5-(hydroxymethyl)phenylboronic Acid (CAS 1003042-59-8)
- 3-Chloro-4-(hydroxymethyl)phenylboronic Acid (CAS 1190875-60-5)
- 4-Chloro-2-hydroxy-6-methylphenylboronic acid (CAS 1207961-50-9)
- (4-Chloro-2-(hydroxymethyl)phenyl)boronic acid (CAS 1365244-07-0)
- 4-Chloro-3-(hydroxymethyl)phenylboronic acid (CAS 1430237-54-9)
- 3-Chloro-2-hydroxymethylphenylboronic acid (CAS 1451393-57-9)
- 3-Chloro-4-methoxyphenylboronic Acid (CAS 175883-60-0)
- 3-Chloro-2-methoxyphenylboronic Acid (CAS 179898-50-1)
Recommended Standards
- 2-Chloro-3-methoxyphenylboronic Acid (CAS 854778-30-6)
- 2-Chloro-5-methoxyphenylboronic Acid (CAS 89694-46-2)
- (4-Chloro-2-ethylpyrimidin-5-yl)boronic acid (CAS 2225169-99-1)
- 2-Chloro-6-methoxyphenylboronic acid (CAS 385370-80-9)
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