Chlorthalidone EP Impurity H CAS 2200280-98-2
| CAS No. | 2200280-98-2 |
| Molecular Formula | C17H17ClN2O4S |
| Molecular Weight | 380.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Chlorthalidone EP Impurity H (CAS 2200280-98-2) is a certified pharmaceutical impurity reference standard with the molecular formula C17H17ClN2O4S and a molecular weight of 380.85 g/mol.
Structurally, Chlorthalidone EP Impurity H (C17H17ClN2O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 380.85 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17ClN2O4S |
| Molecular Weight | 380.85 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorthalidone Standards
- Chlorthalidone impurity 20 (CAS 96512-76-4)
- Chlorthalidone impurity 17 (CAS CATO-C4X-158517)
- Chlorthalidone-d4 (CAS 1794941-44-8)
- Chlorthalidone impurity 19 (CAS CATO-C4X-158519)
- Chlorthalidone Impurity 7 (CAS 345930-31-6)
- Chlorthalidone (CAS 77-36-1)
- Chlorthalidone impurity 16 (CAS CATO-C4X-158516)
- Chlorthalidone Impuruty 8 (CAS 82875-49-8)
Recommended Standards
- N-(4-chlorophenyl)-2-((2-cyanophenyl)sulfinyl)benzamide (CAS 477710-66-0)
- 2,4,6-Tribromo-3-hydroxybenzoic acid (CAS 14348-40-4)
- Methyl 2-{[4-(4-chlorophenyl)-3-cyano-2-pyridinyl]sulfanyl}benzenecarboxylate (CAS 478080-47-6)
- 2-((4-Chlorophenyl)thio)-N-(3-fluoro-4-morpholinophenyl)acetamide (CAS 439112-45-5)
- Delafloxacin Impurity 11 (CAS CATO-C4X-263711)
- Lafutidine Impurity 7 (CAS 1710725-58-8)
- Carteolol EP Impurity I (CAS 2748462-62-4)
- 3-(4-(Acridine-9-carbonyl)piperazin-1-yl)phenyl benzyl carbonate (CAS 1029773-34-9)
- 5-Chloro-7-((4-ethylphenyl)(pyridin-2-ylamino)methyl)quinolin-8-ol (CAS 713491-57-7)
- (2E)-N-(5-chloro-2-methoxyphenyl)-2-(hydroxyimino)acetamide (CAS 67303-24-6)
- 1-((2-(4-(Difluoromethoxy)Phenyl)-2-Methylpropoxy)Methyl)-3-(4-Fluorophenoxy)Benzene (CAS 80843-63-6)
- tert-Butyl (5-methylfuran-2-yl)carbamate (CAS 62188-16-3)
- 4-Fluoro-7-methoxyindole-3-carboxaldehyde (CAS 1227595-85-8)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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