Chlorthalidone impurity 20 CAS 96512-76-4
| CAS No. | 96512-76-4 |
| Molecular Formula | C15H13ClN2O4S |
| Molecular Weight | 352.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Chlorthalidone impurity 20 (CAS 96512-76-4), a pharmacopoeial impurity reference standard (molecular formula C15H13ClN2O4S, MW 352.79 g/mol) used for the identification and quantification of trace impurities in APIs.
Chlorthalidone impurity 20 (C15H13ClN2O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Chlorthalidone impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13ClN2O4S |
| Molecular Weight | 352.79 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorthalidone Standards
- Chlorthalidone impurity 17 (CAS CATO-C4X-158517)
- Chlorthalidone-d4 (CAS 1794941-44-8)
- Chlorthalidone impurity 19 (CAS CATO-C4X-158519)
- Chlorthalidone Impurity 7 (CAS 345930-31-6)
- Chlorthalidone (CAS 77-36-1)
- Chlorthalidone impurity 16 (CAS CATO-C4X-158516)
- Chlorthalidone EP Impurity H (CAS 2200280-98-2)
- Chlorthalidone Impuruty 8 (CAS 82875-49-8)
Recommended Standards
- Cefaclor Impurity 48 (CAS CATO-C4X-127048)
- 7-ACCA Impurity 1 (CAS CATO-C4X-23131)
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- Tranexamic Impurity 29 (CAS CATO-C4X-177129)
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- (R)-1-((2-Nitrophenyl)sulfonyl)pyrrolidin-3-amine (CAS 1187932-93-9)
- N-(2-Chloro-4,6-dimethylphenyl)-2-((4-ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 578001-91-9)
- Benzyl 2-methylpiperazine-1-carboxylate hydrochloride (CAS 1217720-49-4)
- Methyl4-chloro-2-oxo-1,3-dihydropyrrolo[2,3-b]pyridine-5-carboxylate (CAS 2090335-30-9)
- (2-Bromo-6-methylpyridin-4-yl)boronic acid (CAS 2225181-29-1)
- Benzoxazole, 4-(2-chloro-4-nitrophenoxy)- (CAS 1033810-10-4)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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