Chlorthalidone Impuruty 8 CAS 82875-49-8
| CAS No. | 82875-49-8 |
| Molecular Formula | C14H11ClN2O3S |
| Molecular Weight | 322.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Chlorthalidone Impuruty 8 (CAS 82875-49-8, C14H11ClN2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Chlorthalidone Impuruty 8 (C14H11ClN2O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Chlorthalidone Impuruty 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11ClN2O3S |
| Molecular Weight | 322.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorthalidone Standards
- Chlorthalidone impurity 18 (CAS 87177-16-0)
- Chlorthalidone impurity 16 (CAS CATO-C4X-158516)
- Chlorthalidone Impurity 7 (CAS 345930-31-6)
- Chlorthalidone (CAS 77-36-1)
- Chlorthalidone impurity 19 (CAS CATO-C4X-158519)
- Chlorthalidone-d4 (CAS 1794941-44-8)
- Chlorthalidone RC 3 (CAS 61959-32-8)
- Chlorthalidone EP Impurity G (CAS 16289-13-7)
Recommended Standards
- (E)-N-[(4-{[(4-chlorophenyl)methyl]sulfanyl}-3-nitrophenyl)methylidene]hydroxylamine 12D-005S 303996-06-7 (CAS 303996-06-7)
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- 1,2-Dibromo-3,5-dichloro-4-fluorobenzene (CAS 1160573-90-9)
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- 2-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)benzaldehyde (CAS 1227954-93-9)
- 4733-39-5 9THP2V94FX Bathocuproine 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline 1,10-Phenanthroline, 2,9-dimethyl-4,7-diphenyl- EINECS 225-240-5 NSC 89195 UNII-9THP2V94FX (CAS 4733-39-5)
- 4,6-Dibromo-5-hydroxypicolinic acid (CAS 64354-26-3)
- 3-(1-(2-(Thiophen-3-yl)acetyl)piperidin-4-yl)thiazolidine-2,4-dione (CAS 1798543-05-1)
- Methyl 2-((8-chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)thio)acetate (CAS 1623663-01-3)
- 6-MORPHOLINO-3-PYRIDINYL ISOTHIOCYANATE (CAS 52024-29-0)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
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