Ruxolitinib Impurity 171 CAS 2201066-09-1
| CAS No. | 2201066-09-1 |
| Molecular Formula | C11H16BN3O2 |
| Molecular Weight | 233.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Ruxolitinib Impurity 171 (CAS 2201066-09-1, C11H16BN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ruxolitinib Impurity 171 (C11H16BN3O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.5, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 233.08 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H16BN3O2 |
| Molecular Weight | 233.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 3 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 38 (CAS 1974336-79-2)
- Ruxolitinib Impurity 17 (CAS CATO-C4X-205817)
- Ruxolitinib Impurity 102 (CAS CATO-C4X-2058102)
- Ruxolitinib Impurity 47 (CAS CATO-C4X-205847)
- Ruxolitinib Impurity 228 (CAS CATO-C4X-2058228)
- Ruxolitinib impurity 49 (CAS CATO-C4X-205849)
- Ruxolitinib Impurity 101 (CAS CATO-C4X-2058101)
- Ruxolitinib Impurity 62 (CAS CATO-C4X-205862)
Recommended Standards
- 5-Bromo-6-(2-fluoropropan-2-yl)pyridin-2-amine (CAS 2673369-86-1)
- N′-(2,3-Dichlorophenyl)-N,N-dimethylurea (CAS 10290-37-6)
- 5-Bromo-2-mercaptobenzoic acid (CAS 61954-80-1)
- 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one (CAS 1035219-96-5)
- Xanomeline Impurity 7 (CAS CATO-C4X-33017)
- Atrasentan Impurity 42 (CAS 1349623-84-2)
- Salmeterol EP Impurity A (CAS 1798014-51-3)
- 2779AF 905811-03-2 C15H16N2O N-(5-Amino-2-methylphenyl)-3-methylbenzamide (CAS 905811-03-2)
- 1-Chloro-4-(3-fluorophenoxy)benzene (CAS 1881289-06-0)
- 3-Chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine (CAS 1093759-48-8)
- [(Furan-3-yl)methyl](propan-2-yl)amine (CAS 741698-72-6)
- (2-Phenylquinolin-7-yl)methanol (CAS 361457-37-6)
- Tert-butyl 4-(pyridin-3-yl)piperazine-1-carboxylate (CAS 223797-47-5)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
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