Alprazolam EP Impurity H CAS 2203515-05-1
| CAS No. | 2203515-05-1 |
| Molecular Formula | C34H27Cl2N7O2 |
| Molecular Weight | 636.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Alprazolam EP Impurity H (CAS 2203515-05-1, C34H27Cl2N7O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C34H27Cl2N7O2, Alprazolam EP Impurity H contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 636.53 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C34H27Cl2N7O2 |
| Molecular Weight | 636.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Alprazolam Standards
- Alprazolam impurity 23 (CAS CATO-C4X-146023)
- Alprazolam EP Impurity J (CAS CATO-C4X-146018)
- Alprazolam Impurity 22 (CAS CATO-C4X-146022)
- Alprazolam Impurity 3 (CAS 49691-65-8)
- Alprazolam Impurity 20 (CAS 26381-66-8)
- Alprazolam EP Impurity F (CAS 37945-07-6)
- Alprazolam Impurity 9 (CAS 17387-32-5)
- Alprazolam 5,6-Epoxide (CAS 36916-14-0)
Recommended Standards
- 1-2-3-Tri-O-acetyl-4-O-(2-3-4-6-tetra-O-acetyl-α-D-glucopyranosyl)-β-D-glucopyranose (CAS 56285-96-2)
- Hydrochlorothiazide Impurity 27 (CAS CATO-C4X-117727)
- 2-3-4-Tri-O-acetyl-6-O-(2-3-4-6-tetra-O-acetyl-β-D-glucopyranosyl)-D-glucopyranose (CAS 56253-33-9)
- (1-Methyl-3-phenyl-5-((3-(trifluoromethyl)phenyl)sulfonyl)-1H-pyrazol-4-yl)methyl 3,5-bis(trifluoromethyl)benzoate (CAS 318497-76-6)
- Olmesartan Impurity 79 (CAS 172875-59-1)
- Falecalcitriol impurity 3 (CAS CATO-C4X-31413)
- Azathioprine Impurity 26 (CAS 18753-82-7)
- 7-chloro-2-methyl-1,6-naphthyridin-3-yl trifluoromethanesulfonate (CAS 1455035-96-7)
- 1-(2-Cyanoethyl)-2-oxocyclopentanecarbonitrile (CAS 139624-41-2)
- (Pyrrolidin-2-ylmethyl)urea (CAS 1249108-26-6)
- methyl 5-fluoro-3-methyl-2-oxo-1,3-benzoxazole-7-carboxylate (CAS 2387599-02-0)
- 1-(2-Methylbutyl)-1h-indol-4-amine (CAS 1340456-98-5)
- 2,2’-Difluorobenzil (CAS 573-43-3)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
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