Alprazolam Impurity 20 CAS 26381-66-8
| CAS No. | 26381-66-8 |
| Molecular Formula | C15H9Cl4NO2 |
| Molecular Weight | 377.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Alprazolam Impurity 20.
Alprazolam Impurity 20 (CAS 26381-66-8) is a certified pharmaceutical impurity reference standard with the molecular formula C15H9Cl4NO2 and a molecular weight of 377.05 g/mol.
Alprazolam Impurity 20 (C15H9Cl4NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H9Cl4NO2 |
| Molecular Weight | 377.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Alprazolam Standards
- Alprazolam EP Impurity F (CAS 37945-07-6)
- Alprazolam Impurity 9 (CAS 17387-32-5)
- Alprazolam 5,6-Epoxide (CAS 36916-14-0)
- Alprazolam impurity 21 (CAS 37945-06-5)
- Alprazolam EP Impurity B (CAS 38150-27-5)
- Alprazolam Impurity 22 (CAS CATO-C4X-146022)
- Alprazolam Impurity 3 (CAS 49691-65-8)
- Alprazolam EP Impurity B (CAS CATO-C4X-146014)
Recommended Standards
- 2,2-Dichloro-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)acetamide (CAS CATO-C3D-25937)
- 4-Bromo-2-{[(3,4-dichlorophenyl)amino]methyl}-6-methoxyphenol (CAS 329778-98-5)
- 2-(2-chloroanilino)-N-(2,4-dichlorophenyl)-2-oxoethanehydrazonoyl chloride 2-[(2-chlorophenyl)amino]-N-(2,4-dichlorophenyl)-2-oxidanylidene-ethanehydrazonoyl chloride 861322-29-4 A841568 (CAS 861322-29-4)
- 4-Bromo-2-{[(3,5-dichlorophenyl)amino]methyl}-6-methoxyphenol (CAS 329779-01-3)
- Cinacalcet Impurity 18 (CAS 191155-81-4)
- Bexagliflozin Impurity 11 (CAS CATO-C4X-332211)
- Benidipine Impurity 5 (CAS CATO-C4X-11205)
- Alcian Blue (CAS 12040-44-7)
- 2-(1-Benzyl-1H-indol-3-yl)ethan-1-amine (CAS 4307-98-6)
- N-(2-Fluorophenyl)-6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (CAS 694460-18-9)
- 2-(4-Cyanophenyl)-1H-benzo[d]imidazole-6-carbonitrile (CAS 38224-22-5)
- tert-Butyl methyl(3-methyl-4-oxotetrahydro-2H-pyran-3-yl)carbamate (CAS 2839566-45-7)
- 5-Bromo-2-methoxycinnamic acid (CAS 40803-53-0)
- Neuropeptide Y (3-36) (porcine) trifluoroacetate salt (CAS 143863-88-1)
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