Alprazolam Impurity 3 CAS 49691-65-8
| CAS No. | 49691-65-8 |
| Molecular Formula | C18H14Cl3N3O3 |
| Molecular Weight | 426.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Alprazolam Impurity 3 (C18H14Cl3N3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Alprazolam Impurity 3 (CAS 49691-65-8, C18H14Cl3N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Alprazolam Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl3N3O3 |
| Molecular Weight | 426.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Alprazolam Standards
- Alprazolam Impurity 22 (CAS CATO-C4X-146022)
- Alprazolam Impurity 20 (CAS 26381-66-8)
- Alprazolam EP Impurity F (CAS 37945-07-6)
- Alprazolam Impurity 9 (CAS 17387-32-5)
- Alprazolam 5,6-Epoxide (CAS 36916-14-0)
- Alprazolam impurity 21 (CAS 37945-06-5)
- Alprazolam EP Impurity B (CAS 38150-27-5)
- Alprazolam EP Impurity B (CAS CATO-C4X-146014)
Recommended Standards
- 2-(2-Bromo-6-ethoxy-4-formylphenoxy)-N-(3-chloro-4-methylphenyl)acetamide (CAS 552841-34-6)
- 390362-53-5 Buxbodine D C28H46N2O W1071 (CAS 390362-53-5)
- Ethyl 2-{4-bromo-2-[(1Z)-[(3-chlorophenyl)imino]methyl]-6-methoxyphenoxy}acetate (CAS 338750-67-7)
- Stearoylamide Propylbetaine (CAS 6179-44-8)
- Prulifloxacin impurity 1 (CAS 113046-72-3)
- Gemcitabine Impurity N19 (CAS 1147182-15-7)
- Lamotrigine EP Impurity G (CAS 38943-76-9)
- Epinastine Related Compound A HCl (CAS 1159604-26-8)
- 4,5-Dichloro-2-(2,4-difluorophenyl)pyridazin-3(2H)-one (CAS 107360-91-8)
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- 2-Iodophenyl trifluoromethanesulfonate (CAS 129112-26-1)
- Ethyl 3-(2-((1,4-dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)benzoyl)benzoate (CAS 898755-90-3)
- Ethyl thiazolo[4,5-c]pyridine-2-carboxylate (CAS 911463-38-2)
- Calcineurin Autoinhibitory Peptide (CAS 148067-21-4)
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