5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one CAS 220904-99-4
| CAS No. | 220904-99-4 |
| Molecular Formula | C15H8Br2ClNO2 |
| Molecular Weight | 429.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one.
5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one (CAS 220904-99-4), molecular formula C15H8Br2ClNO2 and molecular weight 429.49 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one (C15H8Br2ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H8Br2ClNO2 |
| Molecular Weight | 429.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-(5-(2-Chloro-5-iodobenzyl)thiophen-2-yl)-2-fluoropyridine (CAS 1131770-46-1)
- 1-Chloro-3,5-di(4-chlorbenzoyl)-2-deoxy-D-ribose (CAS 3601-90-9)
- 7-Chloro-3-(2,4-dichloro-5-isopropoxyphenyl)-2-(methylthio)quinazolin-4(3H)-one (CAS 339099-18-2)
- 3'-Chloro-3-((4-chlorobenzyl)oxy)-2-methyl-5'-(trifluoromethyl)-4H-[1,2'-bipyridin]-4-one (CAS 303151-81-7)
- N-(4-chloro-3-nitrophenyl)-4-[3-(trifluoromethyl)pyridin-2-yl]tetrahydropyrazine-1(2H)-carboxamide (CAS 260798-64-9)
- 5-Chloro-3,4-bis(((4-chlorophenyl)thio)methyl)-1-methyl-1H-pyrazole (CAS 318234-29-6)
- 5-Chloro-4-(((3-chlorophenyl)thio)methyl)-3-(((4-chlorophenyl)thio)methyl)-1-methyl-1H-pyrazole (CAS 318234-33-2)
- 5-Chloro-4-{[(2,3-dichlorophenyl)sulfanyl]methyl}-1-methyl-3-[(phenylsulfanyl)methyl]-1H-pyrazole (CAS 318248-73-6)
Recommended Standards
- 4-(3-(2-(Methylsulfonamido)phenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (CAS 923227-45-6)
- Methyl 2-((3-(2-(4-methoxybenzamido)ethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoate (CAS 872996-34-4)
- 2-{[(4-methoxyphenyl)methyl]sulfanyl}-5-[1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl]-1,3,4-oxadiazole (CAS 477709-80-1)
- N-(3-acetylphenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332909-83-8)
- 1-(2,6-Dimethylphenyl)-3-((5-((2-fluorophenyl)amino)-1,3,4-thiadiazol-2-yl)thio)pyrrolidine-2,5-dione (CAS 742095-19-8)
- 2-(2-Propoxyethoxy)ethane-1-sulfonyl chloride (CAS 1341403-16-4)
- 4-Cyclopropoxy-1-isopropyl-2-(trifluoromethyl)benzene (CAS 1243323-14-9)
- (2, 2- Difluoroethoxy) acetic Acid (CAS 269731-26-2)
- N2,N4,N6-Tris(2-aminoethyl)-1,3,5-triazine-2,4,6-triamine (CAS 103658-99-7)
- 5-((2-Hydroxynaphthalen-1-yl)methyl)-2-methyl-6-phenylpyrimidin-4(3H)-one (CAS 14018-01-0)
- Methyl 2,6-dichloro-5-iodopyrimidine-4-carboxylate (CAS 1136962-00-9)
- Levothyroxine Impurity 52 (CAS CATO-C4X-167852)
- 5-(3-Phenylpropyl)-1,3,4-oxadiazol-2-amine (CAS 1152585-28-8)
- Akt/SKG Substrate Peptide (CAS 276680-69-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com