Erlotinib impurity 139 CAS 2218487-28-4
| CAS No. | 2218487-28-4 |
| Molecular Formula | C22H21N3O6 |
| Molecular Weight | 423.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Erlotinib impurity 139 (C22H21N3O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Erlotinib impurity 139 (CAS 2218487-28-4), a pharmacopoeial impurity reference standard (molecular formula C22H21N3O6, MW 423.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Erlotinib impurity 139 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H21N3O6 |
| Molecular Weight | 423.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib impurity 137 (CAS 1318599-96-0)
- Erlotinib Impurity 7 (CAS 882420-21-5)
- ErlotiniB impurity 37 (CAS CATO-C4X-106937)
- Erlotinib Impurity 15 (CAS CATO-C4X-106915)
- Erlotinib Impurity 91 (CAS 1354727-63-1)
- Erlotinib Impurity 48 (CAS 2055840-54-3)
- Erlotinib impurity 138 (CAS 1318600-03-1)
- Erlotinib Impurity 6 (CAS 882420-22-6)
Recommended Standards
- Cefdinir Impurity 28 (CAS CATO-C4X-121028)
- Ganciclovir EP Impurity J (CAS 177216-32-9)
- Roxadustat impurity (CAS CATO-C4X-2213113)
- PDdB-Pfp (CAS 2101206-44-2)
- Vonoprazan Fumarate Impurity 31 (CAS 2169267-53-0)
- Octreotide EP Impurity A Acetate (CAS CATO-C4X-15208)
- Ibrutinib Impurity 112 (CAS CATO-C4X-1064112)
- (S)-2-Amino-N-cyclopropyl-N-(1-methyl-piperidin-4-ylmethyl)-propionamide (CAS 1292593-73-7)
- N-(3-chloro-4-methylphenyl)-2-(4-(pyridin-2-yl)piperazin-1-yl)acetamide (CAS 477333-98-5)
- (1R,2S)-2-(3-Oxobutyl)cyclopropanecarboxylic acid (CAS 774214-56-1)
- Dopamine Impurity 1 (CAS 50673-96-6)
- [1,2,4]Triazolo[4,3-a]quinoline-1-thiol (CAS 35359-23-0)
- 4-hydroxypiperidine-4-carboxamide hydrochloride (CAS 240400-87-7)
- Insulin Detemir (CAS 169148-63-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com