ErlotiniB impurity 37 CAS CATO-C4X-106937
| CAS No. | CATO-C4X-106937 |
| Molecular Formula | C22H22ClN3O4 |
| Molecular Weight | 427.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including ErlotiniB impurity 37.
CATO supplies ErlotiniB impurity 37 (CAS CATO-C4X-106937), a pharmacopoeial impurity reference standard (molecular formula C22H22ClN3O4, MW 427.88 g/mol) used for the identification and quantification of trace impurities in APIs.
ErlotiniB impurity 37 (C22H22ClN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures ErlotiniB impurity 37 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H22ClN3O4 |
| Molecular Weight | 427.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related ErlotiniB Standards
- Erlotinib Impurity 7 (CAS 882420-21-5)
- Erlotinib impurity 137 (CAS 1318599-96-0)
- Erlotinib impurity 139 (CAS 2218487-28-4)
- Erlotinib Impurity 48 (CAS 2055840-54-3)
- Erlotinib Impurity 15 (CAS CATO-C4X-106915)
- Erlotinib Impurity 91 (CAS 1354727-63-1)
- Erlotinib impurity 138 (CAS 1318600-03-1)
- Erlotinib Impurity 6 (CAS 882420-22-6)
Recommended Standards
- N-[(1E)-{[(2-chloro-6-fluorophenyl)methoxy]imino}methyl]-5-cyano-3-methyl-4-phenylthiophene-2-carboxamide (CAS 338968-36-8)
- Flucloxacillin EP Impurity B (CAS CATO-C4X-16472)
- Ethyl 7-chloro-5-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 6324-16-9)
- 1-(5-Chloro-2-methylphenyl)-N-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 890937-57-2)
- Doxazosin EP Impurity F (CAS 23680-84-4)
- Butylphthalide Impurity 36 (CAS 2245275-82-3)
- Lefamulinum Impurity 42 (CAS CATO-C4X-304742)
- 1-Chloro-5,7-dimethyl-3,4-dihydronaphthalene-2-carbaldehyde (CAS 443305-29-1)
- Tert-butyl ((4R,5R)-5-hydroxyazepan-4-yl)carbamate (CAS 2165676-71-9)
- 1-(Trichloromethyl)-3-(trifluoromethyl)benzene (CAS 16766-90-8)
- 4-{[(4-methyl-1,3-thiazol-2-yl)methyl]amino}pyridine-2-carbonitrile (CAS 1341318-48-6)
- Methyl 2-isothiocyanato-5-methyl-4-phenylthiophene-3-carboxylate (CAS 588682-00-2)
- 3-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyridine (CAS 1214356-58-7)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com