Erlotinib Impurity 48 CAS 2055840-54-3
| CAS No. | 2055840-54-3 |
| Molecular Formula | C24H25N3O5 |
| Molecular Weight | 435.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Erlotinib Impurity 48 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Erlotinib Impurity 48 (CAS 2055840-54-3, C24H25N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Erlotinib Impurity 48 (C24H25N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 435.47 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25N3O5 |
| Molecular Weight | 435.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- ErlotiniB impurity 37 (CAS CATO-C4X-106937)
- Erlotinib Impurity 7 (CAS 882420-21-5)
- Erlotinib impurity 137 (CAS 1318599-96-0)
- Erlotinib impurity 139 (CAS 2218487-28-4)
- Erlotinib Impurity 5 (CAS 328528-74-1)
- Erlotinib Impurity 14 (CAS CATO-C4X-106914)
- Erlotinib Impurity 15 (CAS CATO-C4X-106915)
- Erlotinib Impurity 91 (CAS 1354727-63-1)
Recommended Standards
- Trimazosin Hydrochloride (CAS 35795-16-5)
- Tadalafil Impurity 35 (CAS 2169996-11-4)
- N-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(2-oxopyrrolidin-1-yl)benzoyl)piperidine-4-carboxamide (CAS 924254-69-3)
- Tadalafil Impurity 59 (CAS CATO-C4X-108759)
- Darunavir Impurity 20 (CAS 2307745-62-4)
- Cefcapene Impurity 48 (CAS CATO-C4X-182448)
- Lenvatinib Impurity 151 (CAS 289625-93-0)
- 3-Chloro-4-(3-(dimethylamino)propoxy)aniline (CAS 946729-64-2)
- 1-(Thiophen-2-yl)butan-1-ol (CAS 172508-19-9)
- Benzofuran-4-carbonitrile (CAS 95333-17-8)
- 4-Bromo-N-isopropylbenzenesulfonamide (CAS 1984-27-6)
- 1-Methyl-N-(pyridin-2-ylmethyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 869073-33-6)
- N-(4-Amino-2-methylphenyl)-2-(2-methoxyethoxy)-benzamide (CAS 1020058-02-9)
- Tetrapeptide-3 (CAS 827306-97-8)
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