Tramadol Impurity 18 CAS 22204-88-2
| CAS No. | 22204-88-2 |
| Molecular Formula | C16H25NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tramadol Impurity 18 (CAS 22204-88-2), a pharmacopoeial impurity reference standard (molecular formula C16H25NO2HCl, MW 299.84 g/mol) used for the identification and quantification of trace impurities in APIs.
Tramadol Impurity 18 (C16H25NO2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H25NO2 HCl |
| Molecular Weight | 299.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tramadol Standards
- (+)-Tramadol-D6 Hydrochloride (CAS 1109217-84-6)
- Tramadol-d6 HCl (N,N-dimethyl-d6) (mixture of diastereomers) (CAS 1189374-50-2)
- (-)-Tramadol (CAS 123134-25-8)
- Tramadol N-Oxide (CAS 147441-56-3)
- (-)-Tramadol Hydrochloride (CAS 148229-79-2)
- Tramadol EP Impurity A (CAS 152538-36-8)
- Tramadol Impurity 2 (CAS 187219-95-0)
- Tramadol Impurity 1 (CAS 1884-42-0)
Recommended Standards
- Melatonin impurity 18 (CAS 515128-09-3)
- Celiprolol Impurity 9 (CAS CATO-C4X-24549)
- Conjugated Estrogens EP Impurity C (CAS 16680-49-2)
- 8-Methyl-3-(trifluoromethyl)-8-azabicyclo[3.2.1]octan-3-amine (CAS 1341551-33-4)
- Benzyl 2-(4-(trifluoromethyl)phenyl)-2,5-dihydro-1H-pyrrole-1-carboxylate (CAS 1956381-99-9)
- (R)-2-(1-((Benzyloxy)carbonyl)piperidin-2-yl)acetic acid (CAS 1036403-99-2)
- 2-(1-(2,2,2-Trifluoroethyl)azetidin-3-yl)acetic acid (CAS 1341888-85-4)
- (R)-5-(Piperidine-1-carbonyl)pyrrolidin-2-one (CAS 110958-19-5)
- N-(Pyridin-3-ylmethyl)-2-(thiophene-3-carboxamido)oxazole-4-carboxamide (CAS 1396676-95-1)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com