Conjugated Estrogens EP Impurity C CAS 16680-49-2
| CAS No. | 16680-49-2 |
| Molecular Formula | C18H21NaO5S |
| Molecular Weight | 372.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Conjugated Estrogens EP Impurity C (CAS 16680-49-2, C18H21NaO5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Conjugated Estrogens EP Impurity C (C18H21NaO5S) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.5, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 372.41 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Conjugated Estrogens EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H21NaO5S |
| Molecular Weight | 372.41 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Sulfur Atoms | 1 |
Related Conjugated Standards
- Conjugated Estrogens EP Impurity E (CAS 56086-66-9)
- Conjugated Estrogens EP Impurity F (CAS 16680-50-5)
- Conjugated Estrogens EP Impurity G(Stabilzed with up to 40% Tromethamine) (CAS 61612-83-7)
- Conjugated Estrogens EP Impurity A (CAS 56050-04-5)
- Conjugated Estrogens EP Impurity H (CAS 16680-48-1)
- Conjugated Estrogens Impurity 17 (CAS CATO-C4X-141617)
- Conjugated Linoleic Acid Ethyl Ester, 90% (Mixture of Isomers) (CAS 137142-61-1)
- Conjugated Linoleic Acid Methyl Ester (CAS 1002-79-5)
Recommended Standards
- (E)-tetraethyl hex-3-ene-1,1,6,6-tetracarboxylate (CAS 38134-23-5)
- Formoterol impurity 125 (CAS CATO-C4X-1525125)
- 6(2H)-Benzofuranone,2-(1,3-benzodioxol-5- yl)-3,3a,7,7a-tetrahydro-3a,7a-dimethoxy-3- methyl-5-(2-propenyl)-,(2S,3R,3aS,7aR)- 99340-07-5 (CAS 99340-07-5)
- Iloperidone Impurity 5 (CAS 19417-90-4)
- Daunorubicin Impurity 1 (CAS 1159977-24-8)
- Butylphthalide Impurity 2 (CAS 551-08-6)
- Paliperidone Impurity 63 (CAS 1268058-08-7)
- (1R,3r)-3-(2-chlorophenyl)cyclobutan-1-amine hydrochloride (CAS 1807941-06-5)
- 4-[(3-Oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)carbamoyl]butanoic acid (CAS 866137-37-3)
- Ceftriaxone Impurity 48 (CAS CATO-C4X-116348)
- Pyridoxine Impurity 21 (CAS 96181-47-4)
- Ammonium sebacate (CAS 19402-63-2)
- 2,6-Dimethoxy-5-methylpyridine-3-carboxylic acid (CAS 1879026-28-4)
- Protein Kinase C (alpha) Peptide (CAS 159939-84-1)
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