Cilnidipine impurity 27 CAS 2221936-39-4
| CAS No. | 2221936-39-4 |
| Molecular Formula | C18H20N2O7 |
| Molecular Weight | 376.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cilnidipine impurity 27.
As a process- or degradation-related impurity, Cilnidipine impurity 27 (CAS 2221936-39-4, C18H20N2O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cilnidipine impurity 27 (C18H20N2O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20N2O7 |
| Molecular Weight | 376.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
Related Cilnidipine Standards
- Cilnidipine Impurity 9 (CAS 74936-76-8)
- Cilnidipine Impurity 8 (CAS 123853-41-8)
- Cilnidipine Impurity 28 (CAS 62760-08-1)
- (E)-Cilnidipine Impurity 14 (CAS CATO-C4X-179614)
- (E)-Cilnidipine Impurity 15 (CAS CATO-C4X-179615)
- Cilnidipine impurity 22 (CAS CATO-C4X-179622)
- Cilnidipine impurity 23 (CAS 118431-66-6)
- Cilnidipine Impurity 13 (CAS 1974323-06-2)
Recommended Standards
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- Piperacillin EP Impurity J (CAS 2170771-47-6)
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- Nicardipine Impurity 17 (CAS 85677-95-8)
- Diclofenac Ethyl Ester (Aceclofenac EP Impurity C) (CAS 15307-77-4)
- Lorazepam impurity 9 (CAS CATO-C4X-10419)
- Empagliflozin Impurity 36 (CAS CATO-C4X-106536)
- (S)-5-Guanidino-2-((S)-3-phenyl-2-((S)-pyrrolidine-2-carboxamido)propanamido)pentanoic acid (CAS 23846-09-5)
- 4-(4-Chlorophenyl)-5-[(Z)-2-(4-fluorophenyl)diazen-1-yl]-2-methylpyrimidine (CAS 338962-04-2)
- 2-Chloro-1-cyclopropoxy-3-nitrobenzene (CAS 1243402-05-2)
- N-(3,5-Dibromopyridin-2-yl)benzenesulfonamide (CAS 1111637-62-7)
- 1-(3,3-Dimethylbut-1-En-2-Yl)-3-Fluorobenzene (CAS 146558-44-3)
- N-benzyl-5-iodo-2,6-dimethylpyrimidin-4-amine (CAS 677749-49-4)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
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