Nicardipine Impurity 17 CAS 85677-95-8
| CAS No. | 85677-95-8 |
| Molecular Formula | C18H20N2O7 |
| Molecular Weight | 376.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Nicardipine Impurity 17 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 376.36 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Nicardipine Impurity 17 (CAS 85677-95-8, C18H20N2O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicardipine Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H20N2O7 |
| Molecular Weight | 376.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 2 |
Related Nicardipine Standards
- Nicardipine Impurity 62 (CAS CATO-C4X-171062)
- Nicardipine Impurity 19 (CAS 167963-66-8)
- Nicardipine Impurity 35 (CAS CATO-C4X-171035)
- Nicardipine Impurity 23 (CAS 87966-39-0)
- Nicardipine Impurity 37 (CAS CATO-C4X-171037)
- Nicardipine Impurity 42 (CAS CATO-C4X-171042)
- Nicardipine Impurity 48 (CAS CATO-C4X-171048)
- Nicardipine Impurity 31 (CAS CATO-C4X-171031)
Recommended Standards
- Cefoperazone Impurity 39 (CAS CATO-C4X-114939)
- Piperacillin EP Impurity J (CAS 2170771-47-6)
- 8.O-Debenzoylpaeoniflorin (CAS 23532-11-8)
- S-Piperacillin Impurity J (CAS CATO-C4X-173273)
- Amoxicillin Impurity 93 (CAS CATO-C4X-114893)
- LCZ-696 Impurity 17(S,S) (CAS 1012341-52-4)
- Ceftaroline Impurity 4 (CAS CATO-C4X-14834)
- Brovincamine (CAS 57475-17-9)
- O-(5,6,7,8-tetrahydronaphthalen-2-yl) carbonochloridothioate (CAS 84995-63-1)
- 2-(Dimethylamino)-N,N,N-trimethylethanaminium chloride (CAS 57592-62-8)
- 2-Chloro-6-(piperidin-3-yloxy)pyridine (CAS 1289082-12-7)
- Morpholine-d8 (CAS 342611-02-3)
- N-Ethyl-1H-pyrrolo[2,3-b]pyridin-5-amine (CAS 651744-45-5)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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