Trazodone impurity 68 CAS 2221987-86-4
| CAS No. | 2221987-86-4 |
| Molecular Formula | C10H12ClN3O |
| Molecular Weight | 225.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trazodone impurity 68.
CATO supplies Trazodone impurity 68 (CAS 2221987-86-4), a pharmacopoeial impurity reference standard (molecular formula C10H12ClN3O, MW 225.67 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Trazodone impurity 68 (C10H12ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trazodone impurity 68 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClN3O |
| Molecular Weight | 225.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Trazodone Standards
- Trazodone Impurity 99 (CAS CATO-C4X-177299)
- Trazodone Impurity 90 (CAS CATO-C4X-177290)
- Trazodone Impurity 14 (CAS 333985-72-1)
- Trazodone EP Impurity I (CAS 32229-98-4)
- Trazodone Impurity 71 (CAS CATO-C4X-177271)
- Trazodone impurity 64 (CAS CATO-C4X-177264)
- Trazodone Impurity 103 (CAS CATO-C4X-1772103)
- Trazodone impurity 54 (CAS CATO-C4X-177254)
Recommended Standards
- N-Nitroso Trazodone EP Impurity L (CAS 2219339-13-4)
- Epalrestat Impurity 45 (CAS CATO-C4X-223645)
- Atenolol Impurity 14 (CAS 142037-04-5)
- Epalrestat Impurity 53 (CAS CATO-C4X-223653)
- Roxithromycin EP Impurity K (CAS CATO-C4X-130312)
- Apalutamide Impurity 69 (CAS CATO-C4X-274969)
- Azacitidine Impurity 88 (CAS 16491-66-0)
- 5-Chloro-2-(difluoromethyl)pyridin-3-amine (CAS 1806773-42-1)
- 3-Formamido-4-methylpentanoic acid (CAS 1341482-31-2)
- 6-Nitropyrazolo[1,5-a]pyrimidine (CAS 55405-65-7)
- 5,6-Dihydroxypicolinaldehyde (CAS 1289094-38-7)
- Ethyl 3-amino-1-bromoisoquinoline-4-carboxylate (CAS 125414-82-6)
- Ethyl 2-{[2-(3-chlorophenyl)-6-nitro-1H-1,3-benzimidazol-1-yl]oxy}propanoate (CAS 303149-66-8)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
Why CATO?
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