Atenolol Impurity 14 CAS 142037-04-5
| CAS No. | 142037-04-5 |
| Molecular Formula | C11H12ClNO2 |
| Molecular Weight | 225.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Atenolol Impurity 14 (CAS 142037-04-5, C11H12ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H12ClNO2, Atenolol Impurity 14 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 225.67 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12ClNO2 |
| Molecular Weight | 225.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Atenolol Standards
- Atenolol EP Impurity B (CAS 61698-76-8)
- Atenolol EP Impurity J (CAS 81346-71-6)
- Atenolol impurity 28 (CAS CATO-C4X-154928)
- Atenolol Impurity 25 (CAS CATO-C4X-154925)
- Atenolol Impurity 13 (CAS 72224-25-0)
- Atenolol EP Impurity D (CAS 115538-83-5)
- Atenolol USP Related Compound C (CAS 29122-69-8)
- Atenolol EP Impurity H (CAS 29277-73-4)
Recommended Standards
- 3-CYANO-4-FLUOROBENZENE-1-SULFONYL CHLORIDE 3-CYANO-4-FLUOROBENZENESULFONYL CHLORIDE 3-CYANO-4-FLUOROBENZENESULPHONYL CHLORIDE 351003-23-1 4-FLUORO-3-CYANOBENZENESULFONYL CHLORIDE 4-FLUORO-3-CYANOBENZENESULPHONYL CHLORIDE 5-(CHLOROSULFONYL)-2-FLUOROBENZENECARBONITRILE BENZENESULFONYL CHLORIDE, 3-CYANO-4-FLUORO- XF10062 (CAS 351003-23-1)
- N-Nitroso Trazodone EP Impurity L (CAS 2219339-13-4)
- N-[4-(2-Chloropropanoyl)phenyl]acetamide (CAS 81112-08-5)
- Trazodone impurity 68 (CAS 2221987-86-4)
- Revefenacin Impurity 56 (CAS CATO-C4X-203156)
- Cetirizine EP Impurity A (CAS 303-26-4)
- Avacopan Impurity 10 (CAS CATO-C4X-294510)
- Ethyl 8-(2-chlorophenyl)-8-oxooctanoate (CAS 898759-09-6)
- 6-Bromo-4-chloro-2-phenylquinazoline (CAS 412923-42-3)
- 2-(chloromethyl)-5-methylpyrazine hydrochloride (CAS 128229-06-1)
- Omeprazole Impurity 7 (CAS 103877-02-7)
- Apicidin d2 (CAS 177562-78-6)
- 1-(2-Nitrophenyl)-1H-pyrazole-4-carbonitrile (CAS 90947-37-8)
- 110207-62-0 Acetyl-Cholecystokinin Octapeptide (2-8) (sulfated) MFCD00133565 (CAS 110207-62-0)
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