Afatinib Impurity 92 CAS 2226537-61-5
| CAS No. | 2226537-61-5 |
| Molecular Formula | C14H7F3N4O2 |
| Molecular Weight | 320.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Afatinib Impurity 92 (CAS 2226537-61-5), a pharmacopoeial impurity reference standard (molecular formula C14H7F3N4O2, MW 320.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Afatinib Impurity 92 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 320.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H7F3N4O2 |
| Molecular Weight | 320.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 76 (CAS CATO-C4X-100676)
- Afatinib Impurity 81 (CAS CATO-C4X-100681)
- Afatinib Impurity 83 (CAS CATO-C4X-100683)
- Afatinib Impurity 53 (CAS 1449430-45-8)
- Afatinib Impurity 46 (CAS 1449430-53-8)
- Afatinib Impurity 22 (CAS 162012-67-1)
- Afatinib Impurity 51 (CAS CATO-C4X-100651)
- Afatinib Impurity 54 (CAS 2831861-00-6)
Recommended Standards
- Tetraethyl (1-fluoroethane-1,1-diyl)bis(phosphonate) (CAS 210486-70-7)
- Glycerol Impurity 47 (CAS CATO-C4X-217147)
- tert-butyl N-(6-bromopyrazolo[1,5-a]pyridin-3-yl)carbamate (CAS 2306273-07-2)
- 2-Ethoxy-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one (CAS 1104812-34-1)
- Arotinolol Impurity 40 (CAS CATO-C4X-185440)
- Losartan Impurity 60 (CAS 141949-89-5)
- Alverine Impurity 10 HCl (CAS 27640-12-6(free base))
- 4-Chloro-1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1269702-96-6)
- (2-fluoro-4-hydroxyphenyl)boronic acid (CAS 1376989-43-3)
- 3-Amino-N-(1,1-dioxidotetrahydrothiophen-3-yl)benzamide (CAS 1016704-29-2)
- 1-Isopropyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1120294-63-4)
- 3,3'-Di-tert-pentyl-4H,4'H-[1,1'-binaphthalenylidene]-4,4'-dione (CAS 334634-19-4)
- 2-(Trimethylsilyl)ethyl 4-oxopiperidine-1-carboxylate (CAS 181701-30-4)
- Insulin Degludec Impurity 6 (CAS CATO-C4X-21576)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com