7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid CAS 2227206-26-8
| CAS No. | 2227206-26-8 |
| Molecular Formula | C8H12ClFN2O2 |
| Molecular Weight | 222.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid.
7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid (CAS 2227206-26-8), molecular formula C8H12ClFN2O2 and molecular weight 222.64 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 222.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H12ClFN2O2 |
| Molecular Weight | 222.64 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 3-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 1214360-51-6)
- 4-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214360-53-8)
- 4-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214379-85-7)
- 2-(3-Chloro-4-fluorophenyl)phenol (CAS 1261889-68-2)
- 3'-Chloro-5'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261894-07-8)
- 5-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261897-12-4)
- 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261943-34-3)
- 5-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261969-58-7)
Recommended Standards
- 4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 893736-99-7)
- 4-Chloro-5-fluoro-6-methyl-2-phenylpyrimidine (CAS 1000931-50-9)
- 4-(3-Chloro-4-fluorophenyl)phenol (CAS 22510-31-2)
- 5-(aminocarbonyl)-1-methyl-1H-pyrrole-3-sulfonyl chloride (CAS 1000931-98-5)
- 4-Methyl-2-(4-methylphenyl)-5-(1H-pyrazol-5-yl)-1,3-thiazole (CAS 1397224-18-8)
- 2-Methylquinazoline-4-thiol (CAS 6484-28-2)
- 6,7-Dimethyl-3-(trifluoromethyl)quinoxaline-2-carboxylic acid (CAS 2197053-17-9)
- 5-bromo-2-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 1638763-37-7)
- Methyl Propionate (CAS 554-12-1)
- n1,n1-Diethyl-n2-(tetrahydro-2h-thiopyran-3-yl)ethane-1,2-diamine (CAS 1340102-98-8)
- Pontacyl Carmine 2B (CAS 6625-46-3)
- 1-Bromo-3-chloro-2-methyl-5-nitrobenzene (CAS 1448319-06-9)
- Fmoc-His(Trt))-Ala-Glu-(otBU)-OH (CAS CATO-CPTD789034)
- (D-Ala1)-Peptide T amide (CAS 106362-34-9)
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