4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol CAS 893736-99-7
| CAS No. | 893736-99-7 |
| Molecular Formula | C12H8ClFO |
| Molecular Weight | 222.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol.
CATO supplies 4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 893736-99-7), a certified reference material (molecular formula C12H8ClFO, MW 222.64 g/mol) for analytical method development and quality control.
The molecular framework of 4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (C12H8ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFO |
| Molecular Weight | 222.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 1214360-51-6)
- 4-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214360-53-8)
- 4-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214379-85-7)
- 2-(3-Chloro-4-fluorophenyl)phenol (CAS 1261889-68-2)
- 3'-Chloro-5'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261894-07-8)
- 5-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261897-12-4)
- 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261943-34-3)
- 5-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261969-58-7)
Recommended Standards
- 4-(3-Chloro-4-fluorophenyl)phenol (CAS 22510-31-2)
- 7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid (CAS 2227206-26-8)
- 3-(Difluoromethylthio)benzoyl chloride (CAS 261944-16-5)
- 4-Chloro-5-fluoro-6-methyl-2-phenylpyrimidine (CAS 1000931-50-9)
- Methyl 2'-(5-fluoro-2-methylphenyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-quinoline]-6'-carboxylate (CAS 1353970-91-8)
- 5-(4-Fluorophenyl)-1,3,2-dioxaborinane (CAS 173341-99-6)
- 2-(trifluoromethyl)-1,3-benzothiazole-4-carboxylic acid (CAS 1781508-50-6)
- Methyl 5-phenyl-1H-imidazole-2-carboxylate (CAS 222991-37-9)
- 3-[(4-Methylphenyl)sulfanyl]-1-(4-nitrophenyl)pyrrolidine-2,5-dione (CAS 306732-17-2)
- (Methylthio)methyl acetate (CAS 16437-69-7)
- 3-(Piperazin-1-yl)benzoic acid hydrochloride (CAS 1998216-00-4)
- 4,4-difluorocyclohex-2-en-1-one (CAS 1450597-91-7)
- 1,8A-dihydroindolizine-3,8(2H,5H)-dione (CAS 109070-37-3)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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