4-(3-Chloro-4-fluorophenyl)phenol CAS 22510-31-2
| CAS No. | 22510-31-2 |
| Molecular Formula | C12H8ClFO |
| Molecular Weight | 222.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(3-Chloro-4-fluorophenyl)phenol (CAS 22510-31-2) is a high-purity analytical reference standard with the molecular formula C12H8ClFO and a molecular weight of 222.64 g/mol.
The molecular framework of 4-(3-Chloro-4-fluorophenyl)phenol (C12H8ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures 4-(3-Chloro-4-fluorophenyl)phenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFO |
| Molecular Weight | 222.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 1214360-51-6)
- 4-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214360-53-8)
- 4-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214379-85-7)
- 2-(3-Chloro-4-fluorophenyl)phenol (CAS 1261889-68-2)
- 3'-Chloro-5'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261894-07-8)
- 5-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261897-12-4)
- 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261943-34-3)
- 5-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261969-58-7)
Recommended Standards
- 3-(Difluoromethylthio)benzoyl chloride (CAS 261944-16-5)
- 4'-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 893736-99-7)
- 2-Chloro-4-(4-fluorophenyl)phenol (CAS 860616-69-9)
- 7-chloro-6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid (CAS 2227206-26-8)
- O-Benzyl Alcophosphamide (CAS 55250-96-9)
- Dibenzyl aspartate 4-methylbenzenesulfonate (CAS 4079-62-3)
- Nitrazepam Impurity 2 (CAS 1775-95-7)
- Nemonoxacin Impurity 39 (CAS 221221-39-2)
- 3-(Trifluoromethyl)pyridine-2-sulfonyl chloride (CAS 104040-75-7)
- 5-(4-Acetylphenoxy)furan-2-carboxylic acid (CAS 1263213-08-6)
- 2-(3-(Methoxymethyl)piperidin-1-yl)ethan-1-amine (CAS 1353955-61-9)
- 2-Chloro-1-[3-(furan-2-yl)-5-(thiophen-2-yl)-4,5-dihydro-1h-pyrazol-1-yl]ethan-1-one (CAS 796106-54-2)
- 5-Bromo-3,3-difluoro-1-methyl-2,3-dihydro-1H-indol-2-one (CAS 1630906-88-5)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com