Dolutegravir Impurity 34 CAS 2227442-13-7
| CAS No. | 2227442-13-7 |
| Molecular Formula | C21H21F2N3O5 |
| Molecular Weight | 433.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 433.41 g/mol gives Dolutegravir Impurity 34 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Dolutegravir Impurity 34 (CAS 2227442-13-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H21F2N3O5 and a molecular weight of 433.41 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Dolutegravir Impurity 34 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 433.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dolutegravir Impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H21F2N3O5 |
| Molecular Weight | 433.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 15 (CAS 2384108-28-3)
- Dolutegravir Impurity 35 (CAS 2583719-57-5)
- Dolutegravir Impurity 42 (CAS CATO-C4X-162042)
- Dolutegravir Impurity 58 (CAS 2244245-35-8)
- Dolutegravir Impurity 69 (CAS CATO-C4X-162069)
- Dolutegravir O-Methyl Impurity (CAS 1335210-35-9)
- Dolutegravir Impurity 62 (CAS CATO-C4X-162062)
- Dolutegravir M3 (CAS 1485692-24-7)
Recommended Standards
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- CAS 2140807-17-4 (CAS 2140807-17-4)
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- Neostigmine impurity 46 (CAS CATO-C4X-204246)
- Bisoprolol Impurity 63 (CAS 704200-67-9)
- Bendamustine Impurity N20 (CAS 1219709-86-0)
- Alectinib impurity 22 (CAS CATO-C4X-283622)
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- 5-Chloro-2-methoxy-N-(5-(propylthio)-1,3,4-thiadiazol-2-yl)benzamide (CAS 391875-17-5)
- 4-(2-Fluorophenyl)-5-(methylsulfonyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile (CAS 1447958-48-6)
- Methyl 2-amino-4-bromo-3-cyano-5-fluorobenzoate (CAS 1878218-27-9)
- Buspirone N-Oxide (CAS 220747-81-9)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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