Dolutegravir Impurity 69 CAS CATO-C4X-162069
| CAS No. | CATO-C4X-162069 |
| Molecular Formula | C21H21F2N3O5 |
| Molecular Weight | 433.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dolutegravir Impurity 69 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dolutegravir Impurity 69 (CAS CATO-C4X-162069, C21H21F2N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dolutegravir Impurity 69 (C21H21F2N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 433.41 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Dolutegravir Impurity 69 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H21F2N3O5 |
| Molecular Weight | 433.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 15 (CAS 2384108-28-3)
- Dolutegravir Impurity 34 (CAS 2227442-13-7)
- Dolutegravir Impurity 35 (CAS 2583719-57-5)
- Dolutegravir Impurity 42 (CAS CATO-C4X-162042)
- Dolutegravir Impurity 58 (CAS 2244245-35-8)
- Dolutegravir O-Methyl Impurity (CAS 1335210-35-9)
- Dolutegravir Impurity 62 (CAS CATO-C4X-162062)
- Dolutegravir M3 (CAS 1485692-24-7)
Recommended Standards
- Cabotegravir Impurity 14 (CAS CATO-C4X-287614)
- Cabotegravir Impurity 15 (CAS CATO-C4X-287615)
- Cabotegravir Impurity 17 (CAS CATO-C4X-287617)
- GSK2636771 (CAS 1372540-25-4)
- Imrecoxib Impurity 56 (CAS CATO-C4X-237956)
- Dapagliflozin Impurity 201 (CAS CATO-C4X-1138201)
- Ceftizoxime Impurity 90 (CAS CATO-C4X-179390)
- 1-(4-Ethylcyclohexyl)-5-methylpyrrolidin-2-one (CAS 764717-98-8)
- 1-(3,4-DIFLUORO-PHENYL)-PIPERIDIN-4-ONE 1-(3,4-difluorophenyl)piperidin-4-one 885275-07-0 (CAS 885275-07-0)
- 1,6-Dimethylquinolin-4(1H)-one (CAS 325856-06-2)
- 2-Chloro-n-[(5-methylthiophen-2-yl)methyl]acetamide (CAS 1248069-94-4)
- N2-Butyl-N4-(3,5-dimethylphenyl)-L-asparagine (CAS 1047677-75-7)
- 1-(2-Methoxy-3,4-dimethylphenyl)ethan-1-one (CAS 147623-18-5)
- Semaglutide Impurity 137 (x TFA Salt) (CAS CATO-C4X-2226137)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com