Eltrombopag Impurity 43 CAS 223127-00-2
| CAS No. | 223127-00-2 |
| Molecular Formula | C13H10O3 |
| Molecular Weight | 214.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Eltrombopag Impurity 43 (CAS 223127-00-2, C13H10O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Eltrombopag Impurity 43 (C13H10O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 214.22 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10O3 |
| Molecular Weight | 214.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
Related Eltrombopag Standards
- Eltrombopag Impurity 57 (CAS 893736-72-6)
- Eltrombopag Impurity 31 (CAS 4291-30-9)
- Eltrombopag Impurity 30 (CAS CATO-C4X-119830)
- Eltrombopag Impurity 34 (CAS 13073-25-1)
- Eltrombopag Impurity 37 (CAS 7693-52-9)
- Eltrombopag Impurity 102 (CAS 118048-94-5)
- Eltrombopag Impurity 119 (CAS CATO-C4X-1198119)
- Eltrombopag Impurity 123 (CAS CATO-C4X-1198123)
Recommended Standards
- Terbutaline impurity 69 (CAS 39642-87-0)
- 3-((4-Hydroxyphenyl)amino)-4-iminocyclohexa-2,5-dien-1-one (CAS 1332075-11-2)
- Pioglitazone impurity 56 (CAS 1258625-43-2)
- rel-(1R,2S,3R,4S)-2,3-Dimethy1-7-oxabicyclo[2.2. 1]heptane-2,3-dicarb oxylic acid (CAS 28874-45-5)
- Testosterone Impurity 29 (CAS CATO-C4X-243229)
- Cefdinir Impurity 42 (CAS CATO-C4X-121042)
- Posaconazole Impurity 279 (CAS CATO-C4X-1208279)
- 4-Phenyl-5-((quinolin-8-yloxy)methyl)-4H-1,2,4-triazole-3-thiol (CAS 73511-58-7)
- 2-(1-(Aminomethyl)cyclopropyl)ethan-1-amine (CAS 1494619-13-4)
- 5-(4-Chlorophenyl)nicotinaldehyde (CAS 887973-65-1)
- 2,7-Dimethyloctahydroindolizine (CAS 786640-32-2)
- (4-Bromo-3-methylphenylcarbonyl)pyrrolidine (CAS 149105-15-7)
- Relugolix Impurity 28 (CAS CATO-C4X-242928)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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