Cholecalciferol EP Impurity D CAS 22350-43-2
| CAS No. | 22350-43-2 |
| Molecular Formula | C27H44O |
| Molecular Weight | 384.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cholecalciferol EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Cholecalciferol EP Impurity D (CAS 22350-43-2), a pharmacopoeial impurity reference standard (molecular formula C27H44O, MW 384.64 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, a hydroxyl group, an ether linkage, Cholecalciferol EP Impurity D is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 384.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C27H44O |
| Molecular Weight | 384.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
Related Cholecalciferol Standards
- trans-Cholecalciferol (CAS 1260149-80-1)
- Cholecalciferol EP Impurity A (CAS 22350-41-0)
- Cholecalciferol Impurity 15 (CAS 42607-12-5)
- Cholecalciferol EP Impurity B (CAS 434-16-2)
- Cholecalciferol EP Impurity C (CAS 5226-01-7)
- Cholecalciferol EP Impurity E (CAS 17592-07-3)
- Cholecalciferol-d6 (Vitamin D3-d6) (CAS 118584-54-6)
- Cholecalciferol Impurity 26 (CAS CATO-C4X-158626)
Recommended Standards
- Precalciferol (Previtamin D3) (CAS 1173-13-3)
- Cholesterol EP Impurity C (CAS 651-54-7)
- Cholesterol Impurity 17 (CAS 14214-69-8)
- Vitamin D3 Impurity 4 (CAS 573951-39-0)
- Perampanel Impurity 19 (CAS CATO-C4X-243019)
- Apremilast Impurity 41 (CAS 1450657-31-4)
- Revefenacin impurity 111 (CAS CATO-C4X-2031111)
- Letermovir Impurity 16 (CAS CATO-C4X-291516)
- Methyl 3-amino-3-(3-chloro-4-methoxyphenyl)propanoate (CAS 1466044-61-0)
- (R)-1-(3-chloro-5-fluorophenyl)propan-1-amine (CAS 1212961-48-2)
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- 5,6-Dimethyl-1H-benzo[d]imidazol-1-amine (CAS 78288-57-0)
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- [D-His]-Semaglutide B (x TFA Salt) (CAS CATO-C4X-2226117)
Why CATO?
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