Posaconazole Impurity 144 CAS 2243785-81-9
| CAS No. | 2243785-81-9 |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Posaconazole Impurity 144.
Posaconazole Impurity 144 (CAS 2243785-81-9) is a certified pharmaceutical impurity reference standard with the molecular formula C13H20N2O2 and a molecular weight of 236.31 g/mol.
Posaconazole Impurity 144 (C13H20N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
Related Posaconazole Standards
- Posaconazole Impurity 33 (CAS 170985-85-0)
- Posaconazole Impurity 120 (CAS CATO-C4X-1208120)
- Posaconazole Impurity 143 (CAS 1428118-40-4)
- Posaconazole impurity 242 (CAS CATO-C4X-1208242)
- Posaconazole Impurity 84 (CAS 122151-32-0)
- Posaconazole Impurity 265 (CAS CATO-C4X-1208265)
- Posaconazole Impurity 145 (CAS CATO-C4X-1208145)
- Posaconazole Impurity 81 (CAS 165115-73-1)
Recommended Standards
- Buspirone Impurity 22 (CAS 223461-35-6)
- Rivastigmine USP Related Compound B (CAS 25081-93-0)
- N-((4-amino-2-propylpyrimidin-5-yl)methyl)butyramide (CAS 725-46-2)
- Rivastigmine EP Impurity B (CAS 1230021-28-9)
- Letermovir Impurity 132 (CAS CATO-C4X-2915132)
- Regorafenib Impurity 9 (CAS CATO-C4X-10479)
- Bempedoic Acid Impurity 40 (CAS CATO-C4X-218940)
- 2-(5-Nitro-1H-indol-1-yl)propanoic acid (CAS 1491585-33-1)
- 2-(4-Methoxyphenyl)-1-hydrazinecarbothioamide (CAS 7382-39-0)
- Methyl 2-(5-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-1,2,4-triazol-1-yl)acetate (CAS 1823184-20-8)
- Dimethyl 2-(1-(4-methoxyphenyl)-1H-1,2,3-triazole-4-carbonyl)succinate (CAS 477871-84-4)
- N-(3-Chloro-4-fluorophenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 346600-34-8)
- 6-Amino-4-cyclopropoxypyridine-3-sulfonamide (CAS 1243458-86-7)
- Semaglutide impurity 78 (CAS CATO-C4X-222678)
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