Posaconazole Impurity 145 CAS CATO-C4X-1208145
| CAS No. | CATO-C4X-1208145 |
| Molecular Formula | C12H14F2O3 |
| Molecular Weight | 244.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 244.23 g/mol gives Posaconazole Impurity 145 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Posaconazole Impurity 145 (CAS CATO-C4X-1208145), a pharmacopoeial impurity reference standard (molecular formula C12H14F2O3, MW 244.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Posaconazole Impurity 145 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 244.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Posaconazole Impurity 145 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14F2O3 |
| Molecular Weight | 244.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Posaconazole Standards
- Posaconazole Impurity 117 (CAS CATO-C4X-1208117)
- Posaconazole Impurity 86 (CAS CATO-C4X-1208186)
- Posaconazole Impurity 271 (CAS 159276-57-0)
- Posaconazole Impurity 33 (CAS 170985-85-0)
- Posaconazole Impurity 120 (CAS CATO-C4X-1208120)
- Posaconazole Impurity 143 (CAS 1428118-40-4)
- Posaconazole Impurity 144 (CAS 2243785-81-9)
- Posaconazole impurity 242 (CAS CATO-C4X-1208242)
Recommended Standards
- Roflumilast Impurity 37 (CAS CATO-C4X-108437)
- Cefdinir USP Impurity A (CAS 178949-03-6)
- N-(4-fluorobenzyl)tetrazolo[1,5-b]pyridazin-6-amine (CAS 927067-30-9)
- 7-Fluoro-3-methoxy-4-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 1000576-22-6)
- Ritonavir Impurity 30 (CAS 144164-11-4)
- Baloxavir Marboxil Impurity 151 (CAS CATO-C4X-2108151)
- Nerandomilast impurity 7 (CAS CATO-C4X-34737)
- 3,4-Dihydroxybenzophenone (CAS 10425-11-3)
- 7-Amino-2-methyl-6-(pyrrolidin-1-ylmethyl)quinoline-5,8-dione (CAS 61324-57-0)
- 2-(4-Bromophenyl)ethyl cyclopentyl ketone (CAS 898762-10-2)
- 2,2,2-Trifluoroethyl n-(4-bromophenyl)carbamate (CAS 1087788-87-1)
- 2-(2-Cyano-3-fluorophenoxy)ethane-1-sulfonyl chloride (CAS 1342533-24-7)
- Benzyl (((S)-1-((S)-2-aminopropanoyl)pyrrolidin-2-yl)methyl)(isopropyl)carbamate (CAS 1401666-59-8)
- Peptide 439 (CAS CATO-CPTD788439)
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