Abemaciclib Impurity 177 CAS CATO-C4X-2937177
| CAS No. | CATO-C4X-2937177 |
| Molecular Formula | C12H16Cl3N3 |
| Molecular Weight | 308.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Abemaciclib Impurity 177 (CAS CATO-C4X-2937177) is a certified pharmaceutical impurity reference standard with the molecular formula C12H16Cl3N3 and a molecular weight of 308.63 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Abemaciclib Impurity 177 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 308.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Abemaciclib Impurity 177 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16Cl3N3 |
| Molecular Weight | 308.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Abemaciclib Standards
- Abemaciclib Impurity 167 (CAS CATO-C4X-2937167)
- Abemaciclib Impurity 69 (CAS 1873303-32-2)
- Abemaciclib Impurity 70 (CAS 1231930-47-4)
- Abemaciclib Impurity 20 (CAS CATO-C4X-293720)
- Abemaciclib Impurity 157 (CAS CATO-C4X-2937157)
- Abemaciclib Impurity N6 (CAS 1873303-31-1)
- Abemaciclib Impurity 50 (CAS CATO-C4X-293750)
- Abemaciclib Impurity 140 (CAS 2124229-65-6)
Recommended Standards
- 2-Chloro-n-[2-(2,4-dichlorophenyl)pentyl]acetamide (CAS 733796-09-3)
- 4-Chloro-1-((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-1H-pyrazole-3-carboxylic acid (CAS 1006341-09-8)
- 2-(4-Chlorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244087-56-5)
- 1-(7-Chloro-6-nitro-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one (CAS 1097920-65-4)
- Diclofenac sodium Impurity 56 (CAS 221016-39-3)
- Arotinolol impurity 28 (CAS CATO-C4X-185428)
- Octreotide Impurity 15 (CAS CATO-C4X-152015)
- 5,6,7,8-Tetrahydro-5,8-methanoisoquinolin-3-amine (CAS 105275-29-4)
- N-(3-methylbenzyl)-1',4'-dihydro-3'H-spiro[piperidine-4,2'-quinoxalin]-3'-imine (CAS 1170107-93-3)
- 3,6,9,12,15,18,21-Heptaoxatricosan-1-ol, 23-azido- 352439-36-2 CTK1B0700 (CAS 352439-36-2)
- 6-(Benzyloxy)-1H-indazol-5-amine (CAS 1499162-36-5)
- tert-Butyl 3-(1H-1,2,3-triazol-5-yl)azepane-1-carboxylate (CAS 2384722-09-0)
- 5-Azaspiro[2.3]hexane (CAS 39599-52-5)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
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