Vardenafil Impurity 64 CAS 224786-03-2
| CAS No. | 224786-03-2 |
| Molecular Formula | C21H29N5O4S |
| Molecular Weight | 447.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Vardenafil Impurity 64 (CAS 224786-03-2, C21H29N5O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Vardenafil Impurity 64 (C21H29N5O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H29N5O4S |
| Molecular Weight | 447.55 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2021 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Vardenafil Standards
- Vardenafil Impurity 48 (CAS 224785-72-2)
- Vardenafil Impurity N2 (CAS 448184-54-1)
- Vardenafil Impurity 26 (CAS CATO-C4X-101726)
- Vardenafil USP Related Compound E (CAS 448184-46-1)
- Vardenafil EP impurity A (CAS CATO-C4X-101722)
- Vardenafil EP Impurity A (CAS 2169247-39-4)
- Vardenafil Impurity 66 (CAS CATO-C4X-101766)
- Vardenafil Impurity N19 (CAS 2411340-39-9)
Recommended Standards
- N-(2,5-dimethylphenyl)-2-(5-(4-ethoxyphenyl)-6-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetamide (CAS 686336-53-8)
- Brexpiprazole Impurity 170 (CAS CATO-C4X-1131170)
- N-(2-((4-(2-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)-2-phenoxypropanamide (CAS 897611-30-2)
- Brexpiprazole Impurity 171 (CAS CATO-C4X-1131171)
- Terlipressin Impurity 24 X TFA Salt (CAS CATO-C4X-219324)
- Esomeprazole Impurity 66 (CAS 14248-66-9)
- Mirabegron Impurity 32 (CAS 1310279-36-7 (free base))
- Tert-butyl4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]-3,6-dihydro-2h-pyridine-1-carboxylate (CAS 1534381-85-5)
- (4-Methoxybenzyl)-1,2,4-thiadiazol-5-amine (CAS 1443376-74-6)
- (9H-Fluoren-9-ylmethyl)-methyl-amine hydrochloride (CAS 1187930-52-4)
- N-Boc-N'-Mesyl ethylenediamine (CAS 1190044-23-5)
- 4-Chloro-2-nitroanisole (CAS 89-21-4)
- 3-(5-Methyl-1,3,4-oxadiazol-2-yl)-3-phenylpropanoic acid (CAS 1082787-39-0)
- [D-Glu]3-Semaglutide (CAS CATO-C4X-2226253)
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