Tucatinib Impurity 61 (E-Isomer) CAS CATO-C4X-260561
| CAS No. | CATO-C4X-260561 |
| Molecular Formula | C28H32N8O2S |
| Molecular Weight | 544.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tucatinib Impurity 61 (E-Isomer) (CAS CATO-C4X-260561, C28H32N8O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tucatinib Impurity 61 (E-Isomer) (C28H32N8O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 544.67 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tucatinib Impurity 61 (E-Isomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H32N8O2S |
| Molecular Weight | 544.67 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 1 |
Related Tucatinib Standards
- Tucatinib Impurity 55 (CAS CATO-C4X-260555)
- Tucatinib Impurity 60 (CAS CATO-C4X-260560)
- Tucatinib Impurity 51 (CAS CATO-C4X-260551)
- Tucatinib Impurity 4 (CAS 1429755-58-7)
- Tucatinib Impurity 62 (E-Isomer) (CAS CATO-C4X-260562)
- Tucatinib Impurity 15 (CAS CATO-C4X-260515)
- Tucatinib Impurity 64 (CAS CATO-C4X-260564)
- Tucatinib Impurity 1 (CAS CATO-C4X-26051)
Recommended Standards
- Vardenafil Impurity 65 (CAS 224788-55-0)
- N-Formyl-Met-Leu-Phe-o-fluorobenzylamide (CAS 112898-02-9)
- Benzyl-PEG8-THP (CAS 1611489-00-9)
- Acid Blue 1 (CAS 116-95-0)
- Tunodafil Impurity 4 HCl (CAS CATO-C4X-31104)
- Abiraterone Impurity 65 (CAS CATO-C4X-107065)
- Pitavastatin Impurity 41 (CAS CATO-C4X-103741)
- 2-Iodo-N-(1-(thiophen-2-yl)ethyl)aniline (CAS 1038730-98-1)
- 1-(2-Chlorophenyl)-3-((1-(thiophen-2-ylmethyl)piperidin-4-yl)methyl)urea (CAS 1211841-17-6)
- (R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-4-methylpentanoate (CAS 380886-35-1)
- 3-{2-[4-(2-Methoxyethyl)phenoxy]ethyl}piperidinehydrochloride (CAS 1219956-96-3)
- 1-methyl-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-2-one (CAS 1428666-17-4)
- 2,4,6-Tri(pyrrolidin-1-yl)-1,3,5-triazine (CAS 5794-91-2)
- Fragment-[7-31]-Liraglutide (CAS CATO-C4X-199239)
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