Crisaborole Impurity 38 CAS 2254541-79-0
| CAS No. | 2254541-79-0 |
| Molecular Formula | C28H20N2O4 |
| Molecular Weight | 448.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crisaborole Impurity 38 (C28H20N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Crisaborole Impurity 38 (CAS 2254541-79-0), a pharmacopoeial impurity reference standard (molecular formula C28H20N2O4, MW 448.47 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Crisaborole Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H20N2O4 |
| Molecular Weight | 448.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
Related Crisaborole Standards
- Crisaborole impurity 116 (CAS CATO-C4X-2021116)
- Crisaborole lmpurity 98 (CAS CATO-C4X-202198)
- Crisaborole lmpurity 81 (CAS CATO-C4X-202181)
- Crisaborole impurity 126 (CAS CATO-C4X-2021126)
- Crisaborole Impurity 50 (CAS CATO-C4X-202150)
- Crisaborole impurity 123 (CAS CATO-C4X-2021123)
- Crisaborole Impurity 146 (CAS CATO-C4X-2021146)
- Crisaborole lmpurity 79 (CAS CATO-C4X-202179)
Recommended Standards
- Pomalidomide Impurity 39 (CAS 2093416-31-8)
- Ethyl cellulose (CAS 9004-57-3)
- CAS 2446474-09-3 (CAS 2446474-09-3)
- Tert-butyl 4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)piperidine-1-carboxylate (CAS 1389198-23-5)
- Paclitaxel EP Impurity B (CAS 71610-00-9)
- Hydrochlorothiazide Impurity 38 (CAS CATO-C4X-117738)
- Methylprednisolone Impurity 52 (CAS CATO-C4X-191952)
- N-methyl-2-(2,3,4-trimethoxyphenyl)ethan-1-amine (CAS 32042-11-8)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-isopropylphenyl)acetic acid (CAS 1260618-80-1)
- Ethyl 2-(5-chloro-3-methyl-1H-indol-2-yl)acetate (CAS 1169441-61-5)
- Methyl 3-((trifluoromethyl)thio)benzoate (CAS 88489-59-2)
- 4-Chloro-3-cyano-6-(difluoromethyl)pyridine-2-sulfonamide (CAS 1806919-44-7)
- p-Tolunitrile (CAS 104-85-8)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com