Crisaborole Impurity 146 CAS CATO-C4X-2021146
| CAS No. | CATO-C4X-2021146 |
| Molecular Formula | C24H25BN2O5 |
| Molecular Weight | 432.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 432.28 g/mol gives Crisaborole Impurity 146 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Crisaborole Impurity 146 (CAS CATO-C4X-2021146, C24H25BN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Crisaborole Impurity 146 (C24H25BN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole Impurity 146 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H25BN2O5 |
| Molecular Weight | 432.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Crisaborole Standards
- Crisaborole impurity 123 (CAS CATO-C4X-2021123)
- Crisaborole Impurity 50 (CAS CATO-C4X-202150)
- Crisaborole Impurity 21 (CAS CATO-C4X-202121)
- Crisaborole impurity 110 (CAS CATO-C4X-2021110)
- Crisaborole lmpurity 74 (CAS CATO-C4X-202174)
- Crisaborole lmpurity 75 (CAS CATO-C4X-202175)
- Crisaborole Impurity 20 (CAS CATO-C4X-202120)
- Crisaborole impurity 126 (CAS CATO-C4X-2021126)
Recommended Standards
- 2,2'-Dibromo-1,1'-binaphthalene 2-bromo-1-(2-bromonaphthalen-1-yl)naphthalene 74866-28-7 A9570 (CAS 74866-28-7)
- 1-((6-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)piperidine-4-carboxylic acid (CAS 728916-77-6)
- Methyl 3-(2H-1,3-benzodioxol-5-yl)-3-(2,5-dichlorobenzenesulfonamido)propanoate (CAS 866144-35-6)
- 1-(4-Bromophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione (CAS 299408-57-4)
- Ampicillin Impurity 78 (CAS CATO-C4X-144378)
- Phenylephrine Impurity 92 (CAS CATO-C4X-146792)
- Ilaprazole Impurity 31 Hydrochloride (CAS CATO-C4X-1130174)
- 3,4,5-Tris[[3,4,5-tris(octyloxy)phenyl]methoxy]benzoic acid (CAS 1193467-82-1)
- N'-methyl-N'-(2-(methylthio)quinazolin-4-yl)benzohydrazide (CAS 341968-20-5)
- tert-butyl 4-(3-bromopropyl)piperazine-1-carboxylate (CAS 655225-02-8)
- Bithionol (CAS 97-18-7)
- 2-(Naphthalen-1-yl)acetyl Chloride (CAS 5121-00-6)
- 1-(2-(benzothiazol-2-ylthio)acetyl)-4-(4-chlorophenyl)semicarbazide (CAS 155820-98-7)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com