Bumetanide Impurity 32 CAS 22892-95-1
| CAS No. | 22892-95-1 |
| Molecular Formula | C7H3Cl2NO6S |
| Molecular Weight | 300.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 300.07 g/mol gives Bumetanide Impurity 32 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Bumetanide Impurity 32 (CAS 22892-95-1, C7H3Cl2NO6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Bumetanide Impurity 32 (C7H3Cl2NO6S) contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bumetanide Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3Cl2NO6S |
| Molecular Weight | 300.07 g/mol |
| Purity | >85% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 66 (CAS CATO-C4X-198666)
- Bumetanide Impurity 57 (CAS CATO-C4X-198657)
- Bumetanide Impurity 65 (CAS CATO-C4X-198665)
- Bumetanide Impurity 126 (CAS CATO-C4X-1986126)
- Bumetanide Impurity 68 (CAS CATO-C4X-198668)
- Bumetanide Impurity 12 (CAS 22893-29-4)
- Bumetanide Impurity 50 (CAS 37531-34-3)
- Bumetanide Impurity 76 (CAS CATO-C4X-198676)
Recommended Standards
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- (S)-1-(2,3-dihydrobenzofuran-6-yl)ethan-1-amine (CAS 1259832-69-3)
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- Ethyl 3-Cyclobutyl-3-oxopropanoate (CAS 24922-01-8)
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