Bumetanide Impurity 12 CAS 22893-29-4
| CAS No. | 22893-29-4 |
| Molecular Formula | C11H15ClN2O4S |
| Molecular Weight | 306.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Bumetanide Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Bumetanide Impurity 12 (CAS 22893-29-4, C11H15ClN2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H15ClN2O4S, Bumetanide Impurity 12 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 306.77 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C11H15ClN2O4S |
| Molecular Weight | 306.77 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 76 (CAS CATO-C4X-198676)
- Bumetanide EP Impurity B (CAS 28328-54-3)
- Bumetanide Impurity 74 (CAS CATO-C4X-198674)
- Bumetanide Impurity 22 (CAS CATO-C4X-198622)
- Bumetanide Impurity 65 (CAS CATO-C4X-198665)
- Bumetanide Impurity 57 (CAS CATO-C4X-198657)
- Bumetanide Impurity 66 (CAS CATO-C4X-198666)
- Bumetanide Impurity 32 (CAS 22892-95-1)
Recommended Standards
- tert-Butyl (4-chloro-3-sulfamoylphenyl)carbamate (CAS 2135570-62-4)
- 2-(3-(3-Chloro-5-fluorophenyl)propanoyl)benzothialdehyde (CAS 898750-40-8)
- Tert-butyl (2-chloro-5-sulfamoylphenyl)carbamate (CAS 889856-21-7)
- 2-(4-((4-Chlorophenyl)(hydroxy)methyl)phenoxy)-2-methylpropan-1-ol (CAS 72577-81-2)
- Pretomanid Impurity 9 (CAS CATO-C4X-26069)
- Finerenone Impurity 275 (E-Isomer) (CAS CATO-C4X-2880275)
- Calcitriol impurity 01 (CAS 2239312-26-4)
- (S)-2-Amino-N-(4-chlorobenzyl)-N-ethyl-3-methylbutanamide (CAS 1354015-00-1)
- 1-Bromo-6-methoxyisoquinolin-3-amine (CAS 26389-90-2)
- 3-Methyl-n-(piperidin-4-yl)pyridin-2-amine trihydrochloride (CAS 1779129-90-6)
- (2,6-Dichlorophenyl)methanesulfonyl chloride (CAS 85952-31-4)
- 4-(2-Furylmethoxy)-3-(trifluoromethyl)aniline (CAS 946662-72-2)
- 5-Norbornene-2-exo,3-exo-dimethanol (CAS 699-95-6)
- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com