Travoprost Impurity 9 CAS 22897-99-0
| CAS No. | 22897-99-0 |
| Molecular Formula | C11H11F3O3 |
| Molecular Weight | 248.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Travoprost Impurity 9.
Travoprost Impurity 9 (CAS 22897-99-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11F3O3 and a molecular weight of 248.20 g/mol.
The molecular framework of Travoprost Impurity 9 (C11H11F3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11F3O3 |
| Molecular Weight | 248.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
Related Travoprost Standards
- Travoprost Impurity 12 (CAS 39746-01-5)
- Travoprost Impurity 6 (CAS 349-82-6)
- Travoprost Impurity 10 (CAS 2218532-66-0)
- Travoprost Impurity 51 (CAS CATO-C4X-192551)
- Travoprost Impurity 53 (CAS CATO-C4X-192553)
- Travoprost Impurity 7 (CAS 39746-00-4)
- Travoprost Impurity 11 (CAS 228729-54-2)
- Travoprost Impurity 59 (CAS CATO-C4X-192559)
Recommended Standards
- N-Isopropyl-4-nitro-2-(trifluoromethyl)aniline (CAS 70339-08-1)
- 2-(5-Cyclopropyl-3-(trifluoromethyl)-1h-pyrazol-1-yl)acetohydrazide (CAS 1001518-93-9)
- Methyl 4-ethoxy-3-(trifluoromethyl)benzoate (CAS 2379321-56-7)
- 5-[(carbamoylmethyl)sulfamoyl]furan-2-carboxylic acid (CAS 1038327-92-2)
- Tryptophan EP Impurity F (CAS 145545-23-9)
- Flurbiprofen Impurity 17 (CAS 78543-08-5)
- Carvedilol impurity 21 (CAS 1261395-96-3)
- N-(2,5-Dimethylphenyl)acetamide (CAS 2050-44-4)
- 2-Bromotetrahydrofuran (CAS 59253-21-3)
- 3-Ethyl-2-((4-fluorobenzyl)thio)quinazolin-4(3H)-one (CAS 882082-72-6)
- (4-Methylpyridin-3-yl)(p-tolyl)methanone (CAS 1187171-89-6)
- 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide (CAS 101234-85-9)
- 2-(Chloromethyl)-7-methyl-4b,5,6,7,8,8a-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(1H)-one (CAS 1264050-81-8)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
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