Empagliflozin impurity 208 CAS CATO-C4X-1065208
| CAS No. | CATO-C4X-1065208 |
| Molecular Formula | C15H14ClIO |
| Molecular Weight | 372.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin impurity 208.
Empagliflozin impurity 208 (CAS CATO-C4X-1065208) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14ClIO and a molecular weight of 372.63 g/mol.
Structurally, Empagliflozin impurity 208 (C15H14ClIO) contains a hydroxyl group, an ether linkage, chlorine/iodine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 372.63 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Empagliflozin impurity 208 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14ClIO |
| Molecular Weight | 372.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 102 (CAS CATO-C4X-1065102)
- Empagliflozin impurity 242 (CAS CATO-C4X-1065242)
- Empagliflozin impurity 246 (CAS CATO-C4X-1065246)
- Empagliflozin impurity 251 (CAS CATO-C4X-1065251)
- Empagliflozin Impurity 80 (CAS CATO-C4X-106580)
- Empagliflozin Impurity 81 (CAS CATO-C4X-106581)
- Empagliflozin Impurity 305 (CAS CATO-C4X-1065305)
- Empagliflozin Impurity 146 (CAS CATO-C4X-1065146)
Recommended Standards
- Dapagliflozin Impurity 127 (CAS CATO-C4X-1138127)
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- Dapagliflozin Impurity 128 (CAS CATO-C4X-1138128)
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