Lifitegrast Impurity 17 CAS 2322380-15-2
| CAS No. | 2322380-15-2 |
| Molecular Formula | C29H25ClN2O7S |
| Molecular Weight | 581.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lifitegrast Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lifitegrast Impurity 17 (CAS 2322380-15-2, C29H25ClN2O7S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lifitegrast Impurity 17 (C29H25ClN2O7S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C29H25ClN2O7S |
| Molecular Weight | 581.04 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 16 (CAS 2322380-18-5)
- Lifitegrast Impurity 119 (CAS CATO-C4X-2409119)
- Lifitegrast Impurity 134 (CAS CATO-C4X-2409134)
- Lifitegrast Impurity 50 (CAS 2762168-17-0)
- Lifitegrast Impurity 160 (CAS CATO-C4X-2409160)
- Lifitegrast Impurity 147 (CAS CATO-C4X-2409147)
- Lifitegrast Impurity 89 (CAS CATO-C4X-240989)
- lifitegrast Impurity 21 (CAS CATO-C4X-240921)
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