Cloxacillin Impurity 18 CAS 25629-50-9
| CAS No. | 25629-50-9 |
| Molecular Formula | C11H7Cl2NO2 |
| Molecular Weight | 256.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cloxacillin Impurity 18.
As a process- or degradation-related impurity, Cloxacillin Impurity 18 (CAS 25629-50-9, C11H7Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Cloxacillin Impurity 18 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 256.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H7Cl2NO2 |
| Molecular Weight | 256.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Cloxacillin Standards
- Cloxacillin Impurity 15 (CAS 1598387-74-6)
- Cloxacillin Impurity 17 (CAS 91059-01-7)
- Cloxacillin Impurity N1 (CAS 4357-94-2)
- Cloxacillin Sodium Impurity 6 (CAS 83817-50-9)
- Cloxacillin Impurity 26 (CAS CATO-C4X-159726)
- Cloxacillin Impurity N2 (CAS 69399-79-7)
- Cloxacillin EP Impurity D (CAS 23598-72-3)
- Cloxacillin Impurity 23 (CAS CATO-C4X-159723)
Recommended Standards
- Brivaracetam Impurity 149 (CAS CATO-C4X-2007149)
- Brivaracetam Impurity 33 (CAS CATO-C4X-200733)
- 3-Iodo-4-methoxy-pyridin-2-ylamine 4379AF 956485-64-6 C6H7IN2O (CAS 956485-64-6)
- Quinclorac-Methyl Ester (CAS 84087-33-2)
- Trelagliptin Impurity 6 (CAS 2087874-94-8)
- Ceftiofur Impurity 7 (CAS CATO-C4X-15817)
- Sorafenib Impurity 39 (CAS CATO-C4X-112439)
- 3-(3-Fluorophenyl)-3-oxopropanoic acid (CAS 1000530-96-0)
- 3-(2-Fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (CAS 868143-08-2)
- 2,2,4,4-Tetramethyl-1,3-cyclobutanediol (mixture of isomers) (CAS 3010-96-6)
- 1-Methyl-1H-benzo[d][1,2,3]triazole-7-carbaldehyde (CAS 120321-75-7)
- N-(2-methylbenzyl)prop-2-en-1-amine hydrochloride (CAS 1049774-26-6)
- Trimethylsilylpyrazole (CAS 18276-53-4)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com